Search by BoMiProt ID - Bomi5421

Primary Information

BoMiProt ID Bomi5421
Protein Name EF-hand domain-containing protein D1/EF-hand domain-containing protein 1/Swiprosin-2
Organism Bos taurus
Uniprot IDQ17QM6
Milk FractionExosomes
Ref Sequence ID NP_001069300.1
Aminoacid Length 236
Molecular Weight 26540
FASTA Sequence Download
Gene Name EFHD1
Gene ID 522462
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells trachea
Protein Function EFhd1, an actin-binding and -bundling protein in the mitochondria, may contribute to the Ca2+-dependent regulation of mitochondrial morphology and energy synthesis.
Biochemical Properties The EF-hand domain-containing protein 1 (EFhd1), a homologous protein of EFhd2 has Ca2+-binding EF-hand motifs.The canonical EF-hand domain has two helix-loop-helix motifs comprising four helices (helix 1, helix 2, helix 3, and helix 4) and forms two hydrophobic clusters (I and II) (Denessiouk et al., 2014). Helices 1 and 4 form hydrophobic cluster I, comprising three aromatic residues, and helices 2 and 3 usually form hydrophobic cluster II, comprising a combination of aromatic, hydrophobic, and polar amino acids.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-53, 228-236
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Mun SA, Park J, Park KR, Lee Y, Kang JY, Park T, Jin M, Yang J, Jun CD, Eom SH. Structural and Biochemical Characterization of EFhd1/Swiprosin-2, an Actin-Binding Protein in Mitochondria. Front Cell Dev Biol. 2021 Jan 18;8:628222. doi: 10.3389/fcell.2020.628222. PMID: 33537316; PMCID: PMC7848108. 2.Two structural motifs within canonical EF-hand calcium-binding domains identify five different classes of calcium buffers and sensors.Denessiouk K, Permyakov S, Denesyuk A, Permyakov E, Johnson MS.PLoS One. 2014; 9(10):e109287. 3.Molecular characterization of mitocalcin, a novel mitochondrial Ca2+-binding protein with EF-hand and coiled-coil domains.Tominaga M, Kurihara H, Honda S, Amakawa G, Sakai T, Tomooka Y.J Neurochem. 2006 Jan; 96(1):292-304. 4.Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions.Dütting S, Brachs S, Mielenz D.Cell Commun Signal. 2011 Jan 18; 9():2.