Primary Information |
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| BoMiProt ID | Bomi5386 |
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| Protein Name | E3 ubiquitin-protein ligase TRIM56/RING-type E3 ubiquitin transferase TRIM56/Tripartite motif-containing protein 56 |
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| Organism | Bos taurus |
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| Uniprot ID | E1BD59 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 732 |
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| Molecular Weight | 79152 |
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| FASTA Sequence |
Download |
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| Gene Name | TRIM56 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. TRIM56 E3 ligase does monoubiquitination of cGAS on Lys-335,which is important for cytosolic DNA sensing and IFNα,IFNβ production to induce anti-DNA viral immunity.an essential component of the TLR3 antiviral signaling pathway .TRIM56 associates with and promotes the ubiquitination (K63 linked ubl conjugation) of stimulator of IFN genes (STING), an innate immune signaling adaptor residing in the endoplasmic reticulum (ER), thereby enhancing cytosolic dsDNA-induced IFN production. |
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| Biochemical Properties | has intrinsic E3 ubiquitin ligase activity that lies in the N-terminal RING domain. C-terminal structural integrity of TRIM56 is critical for mediating protein-protein interaction, also it controls the ability of TRIM56 to promote TLR3 signaling. |
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| PTMs | Phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BD59|TRI56_BOVIN E3 ubiquitin-protein ligase TRIM56 OS=Bos taurus OX=9913 GN=TRIM56 PE=2 SV=1
MVSQGSSPSLLEALSSDFLACKICLEQLRVPKTLPCLHTYCQDCLAQLAEGSRLRCPECR
ESVPVPPAGVAAFKTNFFVNGLLDLVKARAGGDLRAGKPACALCPLMGGASAGGPATARC
LDCADDLCQACADGHRCTRQTHSHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFL
CQPCSQLLCRECRLDPHLDHPCLPLAEAVRARRPGLEELLAGVDNNLAELEATRLAEKEA
LARLREQAAKVVTQVEEASERVLRALLAQKQEVLGQLRAHVEAAEEGARERLGELEGQEQ
VAREAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWVPGPAPCQLPQLELYPGLLD
KNCHLLRLSFEEQLPQKDSGKDGARSQGGDATQPQSRDGVQT*402PNQEDGAKTPKESRAQT*419P
QEDGGTQARVGSRSNKKRKFKGRLKSVSREPS*452PAPGPNLEGSGLLPRPIFFCSFPTRMPG
DKRAPRITGLCPFGSREILVADEQNRALKRFSLNGDYRGAVPVPEGCSPCSVAALQDTVA
FSAAARLYLINHNGEVQWRRALSLCQASHAVAAMPSGDRVAVSVSGHVEVYNMEGSLATR
FIPGGKANRGLRALVFLTTSPQGHFVGSDWQQNSLVVCDGLGQVVGEYRGPGLHGCQPGS
VSVDKKGYIFLTLREVNKVVILDPKGSLLGDFLTAYHGLEKPRVTTMVDGRYLVVSLSNG
TIHVFRVRPLDS |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Seo GJ, Kim C, Shin WJ, Sklan EH, Eoh H, Jung JU. TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing. Nat Commun. 2018 Feb 9;9(1):613. doi: 10.1038/s41467-018-02936-3. PMID: 29426904; PMCID: PMC5807518. 2.Shen Y, Li NL, Wang J, Liu B, Lester S, Li K. TRIM56 is an essential component of the TLR3 antiviral signaling pathway. J Biol Chem. 2012 Oct 19;287(43):36404-13. doi: 10.1074/jbc.M112.397075. Epub 2012 Sep 4. PMID: 22948160; PMCID: PMC3476306. |
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