Search by BoMiProt ID - Bomi5371

Primary Information

BoMiProt ID Bomi5371
Protein Name E3 ubiquitin-protein ligase RNF126/RING finger protein 126
Organism Bos taurus
Uniprot IDQ0II22
Milk FractionWhey
Ref Sequence ID NP_001068782.1
Aminoacid Length 313
Molecular Weight 33954
FASTA Sequence Download
Gene Name RNF126
Gene ID 507447
Protein Existence Status reviewed

Secondary Information

Protein Function ubiquitination oF target proteins. mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates.
Biochemical Properties RING finger domain at the C-terminus, a Zn finger domain at the N-terminus, and an AKT phosphorylation site in the middle.Zn finger domain can directly bind to ubiquitin, and the RING finger domain is essential for its E3 ligase activity, which binds both the E2 and the substrate before transferring an ubiquitin molecule from E2 to the substrate.has two unique regions, a serine-rich domain and an SH3-binding domain.
PTMs Ubiquitinated. May undergo autoubiquitination.Acetylation ,phosphorylation,
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-4, 37-78, 91-144, 201-222, 281-285, 292-313
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs phosphorylated by aKT.AKT phosphorylation site within a potential 14-3-3 binding domain.
Bibliography Zhang R, Liu W, Sun J, Kong Y, Chen C. Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy. Pharmacol Res. 2020 May;155:104748. doi: 10.1016/j.phrs.2020.104748. Epub 2020 Mar 6. PMID: 32147403.