Primary Information |
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| BoMiProt ID | Bomi5368 |
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| Protein Name | E3 ubiquitin-protein ligase MARCH8/Membrane-associated RING finger protein 8/Membrane-associated RING-CH protein VIII/RING-type E3 ubiquitin transferase/MARCHF8/MARCH-VIII |
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| Organism | Bos taurus |
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| Uniprot ID | Q0VD59 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069700.1 |
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| Aminoacid Length | 289 |
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| Molecular Weight | 32780 |
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| FASTA Sequence |
Download |
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| Gene Name | MARCHF8/MARCH8 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta.MARCH8, a RING-finger E3 ligase, ubiquitinates Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment |
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| Biochemical Properties | The RING-CH-type zinc finger domain is required for E3 ligase activity. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 2 disordered segments;(2-70), (246-284) |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (153-175) and (194-216) |
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