Search by BoMiProt ID - Bomi5368

Primary Information

BoMiProt ID Bomi5368
Protein Name E3 ubiquitin-protein ligase MARCH8/Membrane-associated RING finger protein 8/Membrane-associated RING-CH protein VIII/RING-type E3 ubiquitin transferase/MARCHF8/MARCH-VIII
Organism Bos taurus
Uniprot IDQ0VD59
Milk FractionWhey
Ref Sequence ID NP_001069700.1
Aminoacid Length 289
Molecular Weight 32780
FASTA Sequence Download
Protein Existence Status reviewed

Secondary Information

Protein Function  ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta.MARCH8, a RING-finger E3 ligase, ubiquitinates Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment
Biochemical Properties The RING-CH-type zinc finger domain is required for E3 ligase activity.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 2 disordered segments;(2-70), (246-284)
DisProt Annotation
TM Helix Prediction 2TMHs; (153-175) and (194-216)