Search by BoMiProt ID - Bomi5364

Primary Information

BoMiProt ID Bomi5364
Protein Name E3 ubiquitin-protein ligase E3D/Ubiquitin-conjugating enzyme E2C-binding protein/UbcH10-binding protein with a HECT-like domain/HECT-type E3 ubiquitin transferase E3D
Organism Bos taurus
Uniprot IDQ1JQA1
Milk FractionWhey
Ref Sequence ID NP_001069179.1
Aminoacid Length 389
Molecular Weight 43392
FASTA Sequence Download
Gene ID 515386
Protein Existence Status reviewed

Secondary Information

Protein Function role in eye development.UBE3D accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and recognizes the target protein to be degraded.control retinal differentiation and development.
Biochemical Properties Contains HECT like domain which has the active cysteine residue. Position 235-257 on the C-terminal region of protein is imp for interaction with UBE2C
PTMs Acetylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments UBE3D and the ubiquitin-proteasome system may play a role in AMD(Age-related macular degeneration) pathogenic progression.
Bibliography Xia H, Zhang Q, Shen Y, Bai Y, Ma X, Zhang B, Qi Y, Zhang J, Hu Q, Du W, Zhu L, Zhou P, Wang B, Xu H, Huang L, Li X. ube3d, a New Gene Associated with Age-Related Macular Degeneration, Induces Functional Changes in Both In Vivo and In Vitro Studies. Mol Ther Nucleic Acids. 2020 Jun 5;20:217-230. doi: 10.1016/j.omtn.2020.02.010. Epub 2020 Feb 28. PMID: 32200270; PMCID: PMC7090285.