Primary Information |
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| BoMiProt ID | Bomi5330 |
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| Protein Name | Dynein light chain Tctex-type 1/T-complex testis-specific protein 1 homolog |
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| Organism | Bos taurus |
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| Uniprot ID | P63171 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_777045.1 |
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| Aminoacid Length | 113 |
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| Molecular Weight | 12452 |
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| FASTA Sequence |
Download |
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| Gene Name | DYNLT1 |
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| Gene ID | 282380 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | blood |
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| Protein Function | Dynlt1 modulates orexin signaling by regulating OX1R, namely its intracellular localization following ligand-induced internalization. |
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| PTMs | N-acetylation at Meth,Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | (1-10) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release. |
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| Bibliography | 1.Duguay D, Bélanger-Nelson E, Mongrain V, Beben A, Khatchadourian A, Cermakian N. Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. PLoS One. 2011;6(10):e26430. doi: 10.1371/journal.pone.0026430. Epub 2011 Oct 20. PMID: 22028875; PMCID: PMC3197643. |
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