Primary Information
BoMiProt ID	Bomi5328
Protein Name	Dynein light chain roadblock-type 1/Dynein light chain 2A, cytoplasmic
Organism	Bos taurus
Uniprot ID	Q3T140
Milk Fraction	Exosomes
Ref Sequence ID	NP_001029614.1
Aminoacid Length	96
Molecular Weight	10990
FASTA Sequence	Download
Gene Name	DYNLRB1
Gene ID	513342
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	pons
Protein Function	N-acetylglucosamine kinase (NAGK) is a good candidate for promoting dynein activation. Specifically, NAGK interacts with dynein light chain roadblock type 1 (DYNLRB1) to promote dynein functions during mitosis and axonal and dendritic growth.
PTMs	N-acetylation at Alanine
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	1-15, 30-41, 92-96
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	NAGK overexpression significantly reduced numbers of dysfunctional spherical mitochondria and increased numbers of ‘thread-like’ healthy mitochondria in our HD(Huntington’s disease) cellular model, which suggests NAGK promoted ALP activity by dynein activation and consequently reduced ROS levels and mitochondrial damage.
Bibliography	1.Islam MA, Sharif SR, Lee H, Seog D-H, Moon IS. N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points. Exp. Mol. Med. 2015;47:e177–e177. 2.Sharif SR, Islam A, Moon IS. N-acetyl-D-glucosamine kinase interacts with dynein-Lis1-NudE1 complex and regulates cell division. Mol. Cells. 2016;39:669–679. 3. Islam MA, Sharif SR, Lee H, Moon IS. N-acetyl-D-glucosamine kinase promotes the axonal growth of developing neurons. Mol. Cells. 2015;38:876–885. 4.Lee H, Cho S-J, Moon IS. The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites. Mol. Cells. 2014;37:248–256.