Primary Information |
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| BoMiProt ID | Bomi5314 |
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| Protein Name | Dynein assembly factor with WDR repeat domains 1/Outer row dynein assembly protein 16 homolog/WD repeat-containing protein 69 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0P593 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069398.1 |
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| Aminoacid Length | 415 |
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| Molecular Weight | 45857 |
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| FASTA Sequence |
Download |
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| Gene Name | DAW1/WDR69 |
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| Gene ID | 530118 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | This protein is required for the function of motile cilia in the planarian Schmidtea mediterranea. |
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| Biochemical Properties | A single ortholog of DAW1 was identified in the genome of the planarian Schmidtea mediterranea (Smed-daw1). Smed-DAW1 is composed of eight WD repeats, which are 55% identical to the founding member of this protein family (Chlamydomonas reinhardtii ODA16) and 58% identical to human DAW1. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | DAW1 mutations in vertebrates result in multiple developmental abnormalities and early or prenatal lethality, complicating functional assessment of DAW1 in adult structures. |
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| Bibliography | 1.Lesko SL, Rouhana L. Dynein assembly factor with WD repeat domains 1 (DAW1) is required for the function of motile cilia in the planarian Schmidtea mediterranea. Dev Growth Differ. 2020 Aug;62(6):423-437. doi: 10.1111/dgd.12669. Epub 2020 Jun 1. PMID: 32359074; PMCID: PMC7483408. 2. |
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