Primary Information |
---|
BoMiProt ID | Bomi5307 |
---|
Protein Name | Dynamin-1 |
---|
Organism | Bos taurus |
---|
Uniprot ID | Q08DF4 |
---|
Milk Fraction | Whey |
---|
Ref Sequence ID | NP_001070288.1 |
---|
Aminoacid Length | 856 |
---|
Molecular Weight | 96252 |
---|
FASTA Sequence |
Download |
---|
Gene Name | DNM1 |
---|
Gene ID | 508794 |
---|
Protein Existence Status | reviewed |
---|
Secondary Information |
---|
Protein Function | Dynamin 1 supports the microtubule bundle formation and participates in the stabilization of microtubules. |
---|
Biochemical Properties | Dynamins 1-3 contain an N-terminal GTPase, a bundle signaling element, a stalk domain, a phosphoinositide-binding pleckstrin homology domain, and a C-terminal proline and arginine-rich domain. |
---|
Significance in milk | microtubule-binding protein with possible microtubule-based motor activity. |
---|
PTMs | Phosphorylation at Ser 857,Nitration,Methylation |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q08DF4|DYN1_BOVIN Dynamin-1 OS=Bos taurus OX=9913 GN=DNM1 PE=2 SV=1
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVNATTEY*80AEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPI
NLRVY*125SPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLS*306IEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGS*347GDQIDTY*354ELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKCVDMVVSELTATIRKCSEKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKAS*512GNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPTGRRS*774PTSS*778PTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGAS*822PDPFGPPPQVPSRPNRAPPGVPSQPIGSGKSIPS |
---|
Predicted Disorder Regions | 636-649, 742-781, 821-856 |
---|
DisProt Annotation | |
---|
TM Helix Prediction | No TM helices |
---|
Significance of PTMs | mediate synaptic transmission through interactions with multiple endocytic accessory proteins |
---|
Additional Comments | Dynamin 1 is expressed mainly in the brain, whereas dynamin 2 is expressed ubiquitously, and dynamin 3 is localized to the brain, lung and testis. |
---|
Bibliography | 1.La TM, Tachibana H, Li SA, Abe T, Seiriki S, Nagaoka H, Takashima E, Takeda T, Ogawa D, Makino SI, Asanuma K, Watanabe M, Tian X, Ishibe S, Sakane A, Sasaki T, Wada J, Takei K, Yamada H. Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes. FASEB J. 2020 Dec;34(12):16449-16463. doi: 10.1096/fj.202001240RR. Epub 2020 Oct 17. PMID: 33070431. 2.Nakata T, Takemura R, Hirokawa N. A novel member of the dynamin family of GTP-binding proteins is expressed specifically in
the testis. J Cell Sci. 1993;105:1-5. 3.Faelber K, Posor Y, Gao S, et al. Crystal structure of nucleotide-free dynamin. Nature. 2011;477:556-560. 3.. Ford MG, Jennim S, Nunnari J. The crystal structure of dynamin.
Nature. 2011;477:561-566. 4.Wen Xie, Tatyana Adayev, Huiyuan Zhu, Jerzy Wegiel, Andrzej Wieraszko, and Yu-Wen Hwang
Biochemistry 2012 51 (34), 6786-6796
DOI: 10.1021/bi2017798. |