Search by BoMiProt ID - Bomi5303

Primary Information

BoMiProt ID Bomi5303
Protein Name Dynactin subunit 3
Organism Bos taurus
Uniprot IDQ0P5A1
Milk FractionExosomes
Ref Sequence ID NP_001069128.1
Aminoacid Length 186
Molecular Weight 21192
FASTA Sequence Download
Gene Name DCTN3
Gene ID 514327
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  retina 
Protein Function DNC-3 is a core component of dynactin and it physically interacted with DNC-1 and DNC-2 and significantly enhanced the binding ability between DNC-1 and DNC-2 in vitro.
Biochemical Properties Dynactin is a large protein complex comprised of 11 different polypeptide subunits: p150Glued (DCTN1), p50 (DCTN2), p24 (DCTN3), p62 (DCTN4), p25 (DCTN5), p27 (DCTN6), actin-related protein (ARP) 1/11, actin, and actin capping protein (CapZ) α and β.
PTMs N-acetylation at Alanine
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-43, 47-59, 183-185
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Terasawa M, Toya M, Motegi F, Mana M, Nakamura K, Sugimoto A. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Genes Cells. 2010 Nov;15(11):1145-57. doi: 10.1111/j.1365-2443.2010.01451.x. Epub 2010 Oct 21. PMID: 20964796; PMCID: PMC3036819. 2.