Primary Information |
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| BoMiProt ID | Bomi5288 |
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| Protein Name | dTDP-D-glucose 4,6-dehydratase |
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| Organism | Bos taurus |
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| Uniprot ID | A6QLW2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001094629.1 |
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| Aminoacid Length | 355 |
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| Molecular Weight | 40666 |
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| FASTA Sequence |
Download |
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| Gene Name | TGDS |
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| Gene ID | 534594 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | CDP-D-glucose 4,6-dehydratase catalyzes the first irreversible step in the synthesis of this 3,6-dideoxysugar by converting CDP-D-glucose to CDP-4-keto-6-deoxyglucose via an NAD+ -dependent intramolecular oxidation-reduction reaction. |
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| Biochemical Properties | tetrameric enzyme.folds into two domains. The N-terminal region contains a Rossmann fold and provides the platform for NAD(H) binding. The C-terminal motif is primarily composed of alpha-helices and houses the binding pocket for the CDP portion of the CDP-D-xylose ligand. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Koropatkin NM, Holden HM. Structure of CDP-D-glucose 4,6-dehydratase from Salmonella typhi complexed with CDP-D-xylose. Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):365-73. doi: 10.1107/S0907444904033876. Epub 2005 Mar 24. PMID: 15805590. |
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