Search by BoMiProt ID - Bomi5288

Primary Information

BoMiProt ID Bomi5288
Protein Name dTDP-D-glucose 4,6-dehydratase
Organism Bos taurus
Uniprot IDA6QLW2
Milk FractionWhey
Ref Sequence ID NP_001094629.1
Aminoacid Length 355
Molecular Weight 40666
FASTA Sequence Download
Gene Name TGDS
Gene ID 534594
Protein Existence Status reviewed

Secondary Information

Protein Function CDP-D-glucose 4,6-dehydratase catalyzes the first irreversible step in the synthesis of this 3,6-dideoxysugar by converting CDP-D-glucose to CDP-4-keto-6-deoxyglucose via an NAD+ -dependent intramolecular oxidation-reduction reaction. 
Biochemical Properties tetrameric enzyme.folds into two domains. The N-terminal region contains a Rossmann fold and provides the platform for NAD(H) binding. The C-terminal motif is primarily composed of alpha-helices and houses the binding pocket for the CDP portion of the CDP-D-xylose ligand.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Koropatkin NM, Holden HM. Structure of CDP-D-glucose 4,6-dehydratase from Salmonella typhi complexed with CDP-D-xylose. Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):365-73. doi: 10.1107/S0907444904033876. Epub 2005 Mar 24. PMID: 15805590.