Primary Information |
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| BoMiProt ID | Bomi5264 |
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| Protein Name | Dopamine beta-hydroxylase |
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| Organism | Bos taurus |
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| Uniprot ID | P15101 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_851338.1 |
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| Aminoacid Length | 610 |
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| Molecular Weight | 68141 |
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| FASTA Sequence |
Download |
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| Gene Name | DBH |
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| Gene ID | 280758 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Dopamine β hydroxylase (DBH), a key player in the catecholamine biosynthetic pathway, may provide a therapeutic opportunity and should be extensively explored as a target for potent anti-hypertensives. |
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| Biochemical Properties | d dopamine β-hydroxylase (DBH), which converts dopamine to noradrenaline; these enzymes are the main enzymes responsible for catecholamine synthesis. |
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| PTMs | N-Linked Glycosylation at Asn and Proteolytic clevage |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P15101|DOPO_BOVIN Dopamine beta-hydroxylase OS=Bos taurus OX=9913 GN=DBH PE=1 SV=2
MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESIN*177TSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCN*559RSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
|
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| Predicted Disorder Regions | 578-610 |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (12-34) |
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| Significance of PTMs | Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. |
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| Additional Comments | An Essential and Optimal Immunohistochemical Marker for Pheochromocytoma and Sympathetic Paraganglioma |
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| Bibliography | 1.Kimura N. Dopamine β-hydroxylase: An Essential and Optimal Immunohistochemical Marker for Pheochromocytoma and Sympathetic Paraganglioma. Endocr Pathol. 2021 Jun;32(2):258-261. doi: 10.1007/s12022-020-09655-w. Epub 2021 Jan 6. PMID: 33405069. 2.Dey SK, Saini M, Prabhakar P, Kundu S. Dopamine β hydroxylase as a potential drug target to combat hypertension. Expert Opin Investig Drugs. 2020 Sep;29(9):1043-1057. doi: 10.1080/13543784.2020.1795830. Epub 2020 Aug 4. PMID: 32658551. 3.Robertson JG, Desai PR, Kumar A, Farrington GK, Fitzpatrick PF, Villafranca JJ. Primary amino acid sequence of bovine dopamine beta-hydroxylase. J Biol Chem. 1990 Jan 15;265(2):1029-35. PMID: 2295597. |
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