Primary Information
BoMiProt ID	Bomi5242
Protein Name	Dolichol phosphate-mannose biosynthesis regulatory protein/Dolichol-phosphate mannose synthase subunit 2/DPM synthase subunit 2
Organism	Bos taurus
Uniprot ID	Q2KIN1
Milk Fraction	Whey,MFGM
Ref Sequence ID	NP_001039733.1
Aminoacid Length	84
Molecular Weight	9395
FASTA Sequence	Download
Gene Name	DPM2
Gene ID	523737
Protein Existence Status	reviewed
Secondary Information
Protein Function	Dolichol-phosphate-mannose (DPM) synthase generates mannosyl donors for glycosylphosphatidylinositols, N-glycan and protein O- and C-mannosylation.DPM2 stabilizes DPM3 and DPM3 stabilizes DPM1. DPM synthase activity was 10 times higher in the presence of DPM2, indicating that DPM2 also plays a role in the enzymatic reaction.
Biochemical Properties	Mammalian DPM synthase contains catalytic DPM1 and regulatory DPM2 subunits, and that DPM1 requires DPM2 for its stable expression in the endoplasmic reticulum. Human DPM synthase consists of three subunits. The third subunit, DPM3, comprises 92 amino acids associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal portion. The stability of DPM3 was dependent upon DPM2.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	1-4, 78-84
DisProt Annotation
TM Helix Prediction	2TMHs; (13-31), (50-72)
Additional Comments	Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3.Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2.
Bibliography	1.Maeda Y, Tanaka S, Hino J, Kangawa K, Kinoshita T. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. EMBO J. 2000 Jun 1;19(11):2475-82. doi: 10.1093/emboj/19.11.2475. PMID: 10835346; PMCID: PMC212771.