Primary Information |
---|
BoMiProt ID | Bomi5241 |
---|
Protein Name | Dolichol kinase/Transmembrane protein 15 |
---|
Organism | Bos taurus |
---|
Uniprot ID | Q58CR4 |
---|
Milk Fraction | Whey,Exosome,MFGM |
---|
Ref Sequence ID | NP_001030442.2 |
---|
Aminoacid Length | 538 |
---|
Molecular Weight | 59190 |
---|
FASTA Sequence |
Download |
---|
Gene Name | DOLK/TMEM15 |
---|
Gene ID | 526844 |
---|
Protein Existence Status | reviewed |
---|
Secondary Information |
---|
Protein Function | The synthesis of N-linked and O-linked oligosaccharides and GPI anchors require Dol-P-Man, which is a sugar donor. This enzyme is involved in synthesis of the sugar donor. |
---|
PTMs | N linked glycosylation |
---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
---|
Predicted Disorder Regions | NA |
---|
DisProt Annotation | |
---|
TM Helix Prediction | 12TMHs; (19 - 37), (110-132), (136-154), (167-185), (225-247), (254-276), (298-316), (336-354), (358-376), (404-422), (437-459),& (479-497) |
---|
Significance of PTMs | During dilated cardiomyopathy,there is stable and reversible N linked glycosylation. |
---|
Additional Comments | Autosomal recessive dilated cardiomyopathy has been implicated as a congenital disorder of glycosylation in individuals with mutations in dolichol kinase, an essential enzyme in the biosynthesis of glycan precursors. |
---|
Bibliography | Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166 |