Primary Information
BoMiProt ID	Bomi5233
Protein Name	DnaJ homolog subfamily C member 14/J domain protein interacting with viral protein/Jiv
Organism	Bos taurus
Uniprot ID	Q95J56
Milk Fraction	Whey
Ref Sequence ID	NP_776699.1
Aminoacid Length	699
Molecular Weight	78178
FASTA Sequence	Download
Gene Name	DNAJC14
Gene ID	281691
Protein Existence Status	reviewed
Secondary Information
Protein Function	Hsp40 chaperone protein.The C-terminus of DNAJC14, which mediates its multimerization, is required for antiviral activity.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	60-193, 212-229, 414-418, 649-653, 672-699
DisProt Annotation
TM Helix Prediction	1TMH; (325-347)
Additional Comments	Host protein required for replication of several viruses including yellow fever virus, pestiviruses like bovine viral diarrhea virus (BVDV)
Bibliography	1.Yi Z, Sperzel L, Nürnberger C, Bredenbeek PJ, Lubick KJ, Best SM, Stoyanov CT, Law LM, Yuan Z, Rice CM, MacDonald MR. Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator. PLoS Pathog. 2011 Jan 13;7(1):e1001255. doi: 10.1371/journal.ppat.1001255. PMID: 21249176; PMCID: PMC3020928.2.Isken O, Postel A, Bruhn B, Lattwein E, Becher P, Tautz N. CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses. J Virol. 2019 Feb 19;93(5):e01714-18. doi: 10.1128/JVI.01714-18. PMID: 30518653; PMCID: PMC6384085.