Primary Information |
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| BoMiProt ID | Bomi5232 |
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| Protein Name | DnaJ homolog subfamily B member 6/MRJ |
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| Organism | Bos taurus |
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| Uniprot ID | Q0III6 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_776957.2 |
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| Aminoacid Length | 242 |
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| Molecular Weight | 26944 |
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| FASTA Sequence |
Download |
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| Gene Name | DNAJB6 |
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| Gene ID | 282215 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | highest expression in brain and retina and lower levels observed in testis, spleen, heart, liver and kidney. |
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| Protein Function | MRJ (DNAJB6), a member of the heat shock protein 40 family, acts as a molecular chaperone for a wide range of cellular processes. |
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| Biochemical Properties | Mammalian relative of DnaJ (MRJ/DNAJB6) is an Hsp40 family member. The Hsp40 family can be categorized into three major types (I, II, and III), all of which share the ∼70-amino acid J-domain.In type-I Hsp40 proteins, the J-domain is at the N-terminus, followed by the glycine/phenylalanine (G/F)-rich region, the zinc finger domain, and the peptide-binding domain in the C-terminus. Type-II is similar to type-I but lacks a zinc finger domain. Type-III members contain only the J-domain, whose location differs between members. |
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| PTMs | Omega-N-methylation at Arginine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 77-96, 238-242 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | MRJ mutations are linked to human diseases, such as muscular dystrophy and neurodegenerative diseases. |
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| Bibliography | 1.Chuang JZ, Zhou H, Zhu M, Li SH, Li XJ, Sung CH. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. J Biol Chem. 2002 May 31;277(22):19831-8. doi: 10.1074/jbc.M109613200. Epub 2002 Mar 14. PMID: 11896048. 2.Ko SH, Huang LM, Tarn WY. The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection. Front Microbiol. 2019 Dec 11;10:2885. doi: 10.3389/fmicb.2019.02885. PMID: 31921062; PMCID: PMC6917656. 3.Heat shock protein 40: structural studies and their functional implications.Li J, Qian X, Sha B.Protein Pept Lett. 2009; 16(6):606-12. 4.The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones.Qiu XB, Shao YM, Miao S, Wang L.Cell Mol Life Sci. 2006 Nov; 63(22):2560-70. |
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