Primary Information |
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| BoMiProt ID | Bomi5228 |
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| Protein Name | DnaJ homolog subfamily B member 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3MI00 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001028935.1 |
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| Aminoacid Length | 340 |
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| Molecular Weight | 38217 |
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| FASTA Sequence |
Download |
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| Gene Name | DNAJB1 |
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| Gene ID | 538426 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | a member of the heat shock 40 protein family forms a complex with heat shock cognate protein 70 (HSC70) to sequester p53 in the cytosol.negative regulator of apoptosis.binds to and reduces stability via ubiquitin-dependent PDCD5 degradation.DNAJB1 binds to MDM2 in vitro and in vivo through its C-terminus and stabilizes MDM2 ,slows MDM2-mediated degradation thus allowing cancer cell proliferation |
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| Biochemical Properties | The C-terminus of DNAJB1 is essential for its interaction with MDM2 and for MDM2 accumulation |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3MI00|DNJB1_BOVIN DnaJ homolog subfamily B member 1 OS=Bos taurus OX=9913 GN=DNAJB1 PE=2 SV=3
MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRK
REIFDRYGEEGLKGSGPSGGSSGGTNGTSFSYTFHGDPHAMFAEFFGGRNPFDNFFGQRN
GEEGMDIDDPFSGFPMGMGGFTNMNFGRSRPAQEPTRKKQDPPVTHDLRVSLEEIYSGCT
KKMKISHKRLNPDGKSIRNEDKILTIEVKRGWKEGTKITFPKEGDQTSNNIPADIVFVLK
DKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGE
GLPLPKT*307PEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI
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| Predicted Disorder Regions | 73-99, 146-160 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Linking IDs | |
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