Primary Information |
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| BoMiProt ID | Bomi5222 |
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| Protein Name | DNA-directed RNA polymerases I and III subunit RPAC2/RNA polymerases I and III subunit AC2/DNA-directed RNA polymerase I subunit D |
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| Organism | Bos taurus |
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| Uniprot ID | Q1RMG8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069612.1 |
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| Aminoacid Length | 133 |
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| Molecular Weight | 15182 |
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| FASTA Sequence |
Download |
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| Gene Name | POLR1D |
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| Gene ID | 539061 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | DNA dependent RNA polymerase,involved in transcription of DNA into mRNA.Ribosome biogenesis. functional roles in craniofacial morphogenesis. |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-36, 121-133 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Treacher Collins syndrome due to mutation or deficiency of this gene |
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| Bibliography | Noack Watt KE, Achilleos A, Neben CL, Merrill AE, Trainor PA. The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome. PLoS Genet. 2016 Jul 22;12(7):e1006187. doi: 10.1371/journal.pgen.1006187. PMID: 27448281; PMCID: PMC4957770. |
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