Primary Information |
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| BoMiProt ID | Bomi5213 |
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| Protein Name | DNA-binding protein RFX2/Regulatory factor X 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A6QLW9 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001095642.1 |
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| Aminoacid Length | 707 |
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| Molecular Weight | 77673 |
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| FASTA Sequence |
Download |
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| Gene Name | RFX2 |
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| Gene ID | 534475 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | Pachytene spermatocytes and sperms |
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| Protein Function | RFX2 transcription factor is a master regulator of genes required for the haploid phase during spermatogenesis,role in DNA damage responses,morphogenesis, and virulence.Sperm Flagellum Assembly |
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| Biochemical Properties | highly conserved 76-residue winged-helix DNA binding domain. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QLW9|RFX2_BOVIN DNA-binding protein RFX2 OS=Bos taurus OX=9913 GN=RFX2 PE=2 SV=1
MQNSESGSDSPASVALCSSAAAQAPVAQPVTAS*33PQRVLVQAAGSAPKGAQMQPLSLPRVQ
QVTQQVQPAQHVYPAQLQYVEGGDAVFTNGALRTAYAYNPEPQMYAPSSAASYFEAPGGA
QVTVAGSSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDGTRHTLAHTSRSSPATL
EMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDP
VNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPV
HQKPRYRPAQKTDSLGESGSHSSLHSTPEQAMAAQSQHHQQYIDVSHVFPEFPAPDLGSV
LLQESITLHDVKALQLAYRRHCEATLDVVMNLQFHYIEKLWLSFWNSKSSSDGPTSLPAS*420
DEEPEGAVLPKDKLVSLCKCDPVLRWMRTCDHILYQALVEILIPDVLRPVPSTLTQAIRN
FAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQ
MLSDLNRVDFANVQEQASWVCQCEEGVVQRLEQDFKLTLQQQSSLDQWASWLDNVVTQVL
KQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHR
VAEATGETPIAVMGEFNDLASLSLTLLDKGGCVWALPPVHSGGGGSP
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| Predicted Disorder Regions | 1-62, 108-129, 172-177, 309-326, 415-424, 702-707 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | A targeted mutation of Rfx2 was created in mice. Rfx2-/- mice are perfectly viable but show complete male sterility. |
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| Bibliography | 1.Hao B, Clancy CJ, Cheng S, Raman SB, Iczkowski KA, Nguyen MH. Candida albicans RFX2 encodes a DNA binding protein involved in DNA damage responses, morphogenesis, and virulence. Eukaryot Cell. 2009 Apr;8(4):627-39. doi: 10.1128/EC.00246-08. Epub 2009 Feb 27. PMID: 19252121; PMCID: PMC2669197. 2.Wu Y, Hu X, Li Z, Wang M, Li S, Wang X, Lin X, Liao S, Zhang Z, Feng X, Wang S, Cui X, Wang Y, Gao F, Hess RA, Han C. Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis. Sci Rep. 2016 Feb 8;6:20435. doi: 10.1038/srep20435. PMID: 26853561; PMCID: PMC4745085. |
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