Primary Information
BoMiProt ID	Bomi5210
Protein Name	DNA-(apurinic or apyrimidinic site) endonuclease 2/AP endonuclease 2/APEX nuclease 2
Organism	Bos taurus
Uniprot ID	Q5E9N9
Milk Fraction	Whey
Ref Sequence ID	NP_001015577.1
Aminoacid Length	514
Molecular Weight	56938
FASTA Sequence	Download
Gene Name	APEX2
Gene ID	511790
Protein Existence Status	reviewed
Secondary Information
Protein Function	Apurinic/apyrimidinic endonuclease 2 (APE2) is a critical molecule,which upregulates in the proximal tubule cells (PTC) following cisplatin-induced nuclear DNA and mitochondrial DNA damage in cisplatin-treated C57B6J mice
Biochemical Properties	Schizosaccharomyces pombe AP endonuclease, Apn2, binds to the inter-domain connector located between the N- and C-terminal domains of Myh1. This Myh1 inter-domain connector also interacts with the Hus1 subunit of the Rad9-Rad1-Hus1 checkpoint clamp.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	355-461, 496-502
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	APE2 has the potential to prevent acute kidney injury in patients with cisplatin-treated cancer.
Bibliography	1.Jin J, Hwang BJ, Chang PW, Toth EA, Lu AL. Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast. DNA Repair (Amst). 2014 Mar;15:1-10. doi: 10.1016/j.dnarep.2014.01.001. Epub 2014 Feb 1. PMID: 24559510; PMCID: PMC3967872. 2.Hu Y, Yang C, Amorim T, Maqbool M, Lin J, Li C, Fang C, Xue L, Kwart A, Fang H, Yin M, Janocha AJ, Tsuchimoto D, Nakabeppu Y, Jiang X, Mejia-Garcia A, Anwer F, Khouri J, Qi X, Zheng QY, Yu JS, Yan S, LaFramboise T, Anderson KC, Herlitz LC, Munshi NC, Lin J, Zhao J. Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury. Cancer Res. 2021 Feb 1;81(3):713-723. doi: 10.1158/0008-5472.CAN-20-1010. Epub 2020 Dec 7. PMID: 33288657; PMCID: PMC7869671.