Primary Information |
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| BoMiProt ID | Bomi5200 |
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| Protein Name | DNA repair protein RAD51 homolog 4/R51H3/RAD51 homolog D/RAD51-like protein 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2HJ51 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039769.1 |
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| Aminoacid Length | 326 |
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| Molecular Weight | 34651 |
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| FASTA Sequence |
Download |
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| Gene Name | RAD51D/RAD51L3 |
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| Gene ID | 529507 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. |
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| Biochemical Properties | The Rad51 protein in eukaryotic cells is a structural and functional homolog of Escherichia coli RecA with a role in DNA repair and genetic recombination. |
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| PTMs | Acetylated at Lys-168 and deacetylated at Lys-168 by SIRT3,S-nitrosylation at Cysteine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 315-326 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | In Saccharomyces cerevisiae, two of these proteins, Rad55p and Rad57p, form a heterodimer that can stimulate Rad51-mediated DNA strand exchange. |
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| Bibliography | 1.Sigurdsson S, Van Komen S, Petukhova G, Sung P. Homologous DNA pairing by human recombination factors Rad51 and Rad54. J Biol Chem. 2002 Nov 8;277(45):42790-4. doi: 10.1074/jbc.M208004200. Epub 2002 Aug 29. PMID: 12205100. 2.Braybrooke JP, Spink KG, Thacker J, Hickson ID. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. J Biol Chem. 2000 Sep 15;275(37):29100-6. doi: 10.1074/jbc.M002075200. PMID: 10871607. |
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