Primary Information |
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| BoMiProt ID | Bomi5193 |
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| Protein Name | DNA polymerase beta |
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| Organism | Bos taurus |
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| Uniprot ID | Q27958 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029936.1 |
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| Aminoacid Length | 335 |
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| Molecular Weight | 38267 |
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| FASTA Sequence |
Download |
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| Gene Name | POLB |
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| Gene ID | 614688 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | key role in base-excision repair. 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. |
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| Biochemical Properties | contains lyase and polymerase domains.The polymerase domain is composed of the C- (Catalytic), D- (Duplex DNA binding), and N-subdomains (Nascent base pair binding). |
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| PTMs | Acetylation, Isopeptide bond formation, Methylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.Ubiquitinated at Lys-41, Lys-61 and Lys-81,leading to degradation by the proteasome. |
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| Bibliography | 1.Beard WA. DNA polymerase β: Closing the gap between structure and function. DNA Repair (Amst). 2020 Sep;93:102910. doi: 10.1016/j.dnarep.2020.102910. PMID: 33087276; PMCID: PMC7643811. |
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