Search by BoMiProt ID - Bomi5193

Primary Information

BoMiProt ID Bomi5193
Protein Name DNA polymerase beta
Organism Bos taurus
Uniprot IDQ27958
Milk FractionWhey
Ref Sequence ID NP_001029936.1
Aminoacid Length 335
Molecular Weight 38267
FASTA Sequence Download
Gene Name POLB
Gene ID 614688
Protein Existence Status reviewed

Secondary Information

Protein Function key role in base-excision repair. 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap.
Biochemical Properties contains lyase and polymerase domains.The polymerase domain is composed of the C- (Catalytic), D- (Duplex DNA binding), and N-subdomains (Nascent base pair binding).
PTMs Acetylation, Isopeptide bond formation, Methylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.Ubiquitinated at Lys-41, Lys-61 and Lys-81,leading to degradation by the proteasome.
Bibliography 1.Beard WA. DNA polymerase β: Closing the gap between structure and function. DNA Repair (Amst). 2020 Sep;93:102910. doi: 10.1016/j.dnarep.2020.102910. PMID: 33087276; PMCID: PMC7643811.