Primary Information |
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BoMiProt ID | Bomi5191 |
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Protein Name | DNA nucleotidylexotransferase/Terminal addition enzyme/Terminal deoxynucleotidyltransferase/TDT/Terminal transferase |
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Organism | Bos taurus |
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Uniprot ID | P06526 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_803461.1 |
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Aminoacid Length | 509 |
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Molecular Weight | 58296 |
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FASTA Sequence |
Download |
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Gene Name | DNTT/TDT |
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Gene ID | 281120 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | role in the initiation step of DNA replication.Template-independent DNA polymerase which catalyzes the addition of deoxynucleoside 5'-triphosphate to the 3'-end of oligonucleotide primers. |
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Biochemical Properties | Cofactor is Mg2+.The bovine TdT cDNA clone contains an open reading frame coding for 520 amino acids, Mr 59,678.nuclear-localization-sequence (Pro-Arg-Lys-Lys-Arg-Pro-Arg) was conserved in the N-terminal region in the mouse and bovine cDNA clones. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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Predicted Disorder Regions | 1-27, 135-144, 413-419 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Koiwai O, Yokota T, Kageyama T, Hirose T, Yoshida S, Arai K. Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells. Nucleic Acids Res. 1986 Jul 25;14(14):5777-92. doi: 10.1093/nar/14.14.5777. PMID: 3755527; PMCID: PMC311591. |