Primary Information |
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| BoMiProt ID | Bomi5179 |
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| Protein Name | DNA excision repair protein ERCC-6-like/ATP-dependent helicase ERCC6-like |
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| Organism | Bos taurus |
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| Uniprot ID | A6QQR4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001096000.1 |
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| Aminoacid Length | 1242 |
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| Molecular Weight | 140510 |
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| FASTA Sequence |
Download |
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| Gene Name | ERCC6L |
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| Gene ID | 782916 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | cooperates with topoisomerase II in mitosis to promote sister chromatid disjunction.function as a DNA-dependent ATPase that interacts with PLK to form a complex that maintains the chromosome architecture during prometaphase. |
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| Biochemical Properties | ATP binding activity.DNA helicase activity. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QQR4|ERC6L_BOVIN DNA excision repair protein ERCC-6-like OS=Bos taurus OX=9913 GN=ERCC6L PE=2 SV=1
MEVSRGFAEAGALS*14PEQAASYLRYVKEAKEATKNGDLEQALKLFNLAKDIFPNEKVMSRI
QKIQEALEELAEHGDDEFIDVCNSGLLLYQELHNQLYEYQKEGIAFLYSLYRDGRRGGIL
ADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTSLISTWLREFVKWTPGMRVKTFHGPS
KDERTRNLCRIQQRNGVIITTYQMLINNWQQLSSLNGQEFLWDYVILDEAHKIKSSSTKS
AICARAIPASNRILLTGTPIQNNLQELWSLFDFACQGSLLGTLRTFKMEYENPITRAREK
DATPGEKALGFKISENLMAIIKPYFLRRTKEEVQKKKSSNPEVQLSEKSPDVGAICEMPS
LSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSAR
ACGLLNLGAAKFSVQDEIEGEDSSDVDHIDQISDDTLMEESGKMLFLMDLLKKLRDEGHQ
TLVFSQSRRILNIIERLLKNRHFKILRIDGTITHLVEREKRISLFQQNKDYSVFLLTTQV
GGVGLTLTAASRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQ
VFKDSLIRQTTGDKKNPFRYFSKQELRELFTIEDFQNSATQLQLQSLHAAQRRSDKNLDE
HIAFLHSLRIAGISDHDLMYTRDLSVKEELDVIEDSHYIQQRVQKAQFLVESESQNTELL
MERQKMGNEGIWLREPVYQTKKKRPKVNKPQPQPS*755SHLPVYHTQEEISSLMAS*773IIIDDLP
KEDEKDLSRIKLNDTIPQDGRHPCVITLNDDFVTT*815LPKGCGDVEEIFPDSLSGMALQKEA
SQEGFMQESEQESPLASFNYLPSKSARVDLGPNLDQLEDDEVLHHCNPSPANPKTKEYQR
PESNVSVIKIADDDLTAAHSALQDAQANEAKLEEEPLASSGQYACDFNLFLEDSADNGQN
LSS*963QFLEHVEKENSLCGSAANSRAESVHS*989KACLSVDLS*998EEDDEPEEVVNVKIRRKARRID
S*1021DNEDEHTFKDTSSTNPFNTSPFPFLSVKQFDAST*1055PKNDIS*1061LPERFFSPKISDSINKSVN
SRRSLASRRS*1090LINVVLDHVEDMEERLDNSS*1110EAKVVEDHLEEGAEESGDEAPEHTKEDPSR
ETLSSENKSSQLSTSKPGALAQETSPGDPEPLS**1180PQDEAMEAVNDYDTLVLHGK
ELKECGKIQEALDCLVKALDIKSSDPEVMLMTLSLYKQLNKT
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| Predicted Disorder Regions | 836-1059, 1102-1192 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region. |
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| Bibliography | Xie Y, Yu J, Wang F, Li M, Qiu X, Liu Y, Qi J. ERCC6L promotes cell growth and invasion in human colorectal cancer. Oncol Lett. 2019 Jul;18(1):237-246. doi: 10.3892/ol.2019.10297. Epub 2019 Apr 30. PMID: 31289493; PMCID: PMC6540252. |
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