Primary Information |
|---|
| BoMiProt ID | Bomi5173 |
|---|
| Protein Name | DNA annealing helicase and endonuclease ZRANB3/Annealing helicase 2/Zinc finger Ran-binding domain-containing protein 3 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | E1BB03 |
|---|
| Milk Fraction | Whey |
|---|
| Aminoacid Length | 1074 |
|---|
| Molecular Weight | 121768 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | ZRANB3 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | A Replication stress response protein and it stabilizes and resolves stalled replication forks by mechanisms that include fork remodeling to facilitate repair or bypass of damaged templates. |
|---|
| Biochemical Properties | ZRANB3 contains a domain similar in sequence to the HARP domains of SMARCAL1. |
|---|
| Significance in milk | Involved in animal’s growth processes and in response to heat stress. |
|---|
| PTMs | Phosphorylation at Ser |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BB03|ZRAB3_BOVIN DNA annealing helicase and endonuclease ZRANB3 OS=Bos taurus OX=9913 GN=ZRANB3 PE=3 SV=3
MSRGHNIKKSLTPQISCSTSESYKQLDFLPDKLRAKLLPFQKDGITFALRRDGRCMVADE
MGLGKTVQAIGIAYFYKEEWPLLIVVPSSLRYPWTEEIEKWIPELSPEEINVIQNKTDVG
RISTSKVTVLGYGLLTTDAETLIDALNNQNFKVVIVDESHYMKSRSATRSRILLPIVQKA
KRAILLTGTPALGRPEELFMQIEALFPQKFGTWTEYAKRYCNAHVRYFGRRSQWDCRGAS
NLNELHQLLSDIMIRRLKTEVLTQLPPKIRQRIPFDLPSAAAKELNSSFEEWEKLMRDPY
SGATETVMGLITRMFKQTAIAKAGAVKDYIKMMLQNDSLKFLVFAHHLSMLQACTEAVIE
NKTRYIRIDGSVPSSERIHLVNQFQKDPETRVAILSIQAAGQGLTFTAATHVVFAELYWD
PGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDTLMWGMLNRKAQVTGSTLNGRKEKLQAE
EGDKEKWDFLQFAEAWTPNERSEELRDEMLFTHFEKEKQRDIRSFFLPNAKKRQLETSCD
ESRVSQEKNTIVPADPVKTATRGDES*566DLEPEAKKLKSVAIDDPCRPPEEQPCRPGQAEAL
LTFGICKAKAQATTPAFCGEGWQCAFCTYINNSVLPYCEMCENPRGGAVPQIDSLNQTQN
KNKNEKDDSQDTSKKIQTSSDGEKQVLAHSTPEPLAKSKEEISTTESEDRLTPQPGDEQL
KNWPVYDTLMFCASKNTDRIHVYTKDGNQMNCNFIPLDIKLDLWEDLPASFQLKQNRSLI
LRFVREWSSLTAMKQKIIKKSGQLFRSPVLALEEIAKQQTKQNSTKRYITKEDVAAASMD
KVKNDGGHVRLITKGPKPGDPSTKEFLEGGECVPFLNPCTAQGDLILKASTSKGYLQAVD
NEGNPLCLRCQQPTCQTKQERKADAWDSRFCSLKCQEEFWIRSNNSYLRAKVFEIEHGVC
QLCNLNAQELFLRLRDAPKSQRKSLLDATWTSKLPLEQLNEMIRSPGEGHFWQVDHIKPV
SGGGGQCSLDNLQTLCTVCHRERTAQQAKERSQVRRQSLASNHGSDITRFLVKK
|
|---|
| Predicted Disorder Regions | NA |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Additional Comments | ZRANB3 is recruited by binding to polyubiquitinated PCNA. |
|---|
| Bibliography | 1.Badu-Nkansah A, Mason AC, Eichman BF, Cortez D. Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3). J Biol Chem. 2016 Apr 8;291(15):8251-7. doi: 10.1074/jbc.M115.709733. Epub 2016 Feb 16. PMID: 26884333; PMCID: PMC5414104. 2.Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell. 2012 Aug 10;47(3):410-21. doi: 10.1016/j.molcel.2012.05.025. Epub 2012 Jun 14. PMID: 22705370; PMCID: PMC3601832. |
|---|
