Primary Information |
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| BoMiProt ID | Bomi5131 |
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| Protein Name | DIS3-like exonuclease 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A0JN80 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001071624.1 |
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| Aminoacid Length | 1053 |
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| Molecular Weight | 120594 |
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| FASTA Sequence |
Download |
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| Gene Name | DIS3L |
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| Gene ID | 777771 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | hDis3L1 is specifically associated with cytoplasmic exosome complexes, but also implicate that the RNA substrates for hDis3L1 are restricted to the cytoplasm. |
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| Biochemical Properties | The identification of hDis3L1 as an exosomeassociated exoribonuclease indeed suggests that hDis3L1 shares more functional features with the yeast Dis3 protein than hDis3.The ribonuclease assays presented in this study show that
hDis3L1 is a Mg2 þ -dependent exoribonuclease and that this
activity is dependent on its RNB domain. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A0JN80|DI3L1_BOVIN DIS3-like exonuclease 1 OS=Bos taurus OX=9913 GN=DIS3L PE=2 SV=2
MLQKREKVLLLRTFHGRTLRIVREHYLRPSVPCNSPLCPQPATCHNDGKLLSSDVTHYMV
PDWKVVQDYLEILEFPELKGIVFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCVLFANE
FQQSCYLPRERGESMEKWQSRSIYNAAAWYYHHCQDRMPIVMVTEDEEAIQQYGSETGGV
FVISFKNYLDNFWPDLKAAHELCESILQSRRERENESQESHGKEYPEHVPLEVLEAGIKS
GRYIQGTLNVNKHRAQIEAFVRLQGASSKDSDLVSDVLIHGMKARNRSIHGDVVVVELLP
KSEWKGRTTALGENDGDDKALGESPSEPMPTGRVVGILQKNWRDYVVTFPSIEEVQSQGK
NAQKILVTPWDYRIPKIRISTQQAEALQDFRVVVRIDSWESTSMYPNGHFVRVLGRIGDL
EGEIATILVENSISVVPFSEAQMCEMPVNTPENPWKVSSQEEREREDLRKTHLVFSIDPS
GCEDVDDTLSVRALDNGNLELGVHIADVTHFVAPHSYIDIEARTRATTYYLADRRYDMLP
AILSADVCSLLGGVDRYAVSVMWELDKTSYEIKKVWYGRTIIRSAYKLFYEAAQDLLDGN
FSVVKDIPEFKDLDEKSRQAKLEELVWAIRKLTDIARHIRAKRDSCGALELEGVEVRIQL
DEKKNIHDLIPKQPLEVHETVAECMILANHWVAKKIWESFPHQALLRRHPPPHQEFFSEL
RECAKAKGFFIDTRSNKALADSLDNANDPNDPIVNKLLRSMATQAMSNALYFSTGSCAEE
EFHHYGLALDKYTHFTSPIRRYSDIIVHRLLMAAISKDKKMEIQENLFSNKDLEELCRHI
NNRNRAAQHSQKQSTELFQCMYFKDKDPETEERCISDGVIYSIRTNGVLVFIPRFGIKGA
AYLRNKDGLVVSCGPDGHSEWKPGSLQRFQNKITCTTTGGESVTFHLFDHVTVRISVQTS
RCHSDTIRLEIISNKPHMTPDTELLQQCS*989LLLKSDLVKEVTRSVEEAQLAQEVAVNITED
YQKYCQTKGRSLYTLLEEIRDLALLDVSNSYGI
|
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | hDis3L1 seems to accumulate in the cytoplasm, its subcellular localization only partially overlaps with that of the core exosome components, which are found in both the cytoplasm and the nucleus. |
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