Search by BoMiProt ID - Bomi5115

Primary Information

BoMiProt ID Bomi5115
Protein Name Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex/Pyruvate dehydrogenase complex component E2/Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Organism Bos taurus
Uniprot IDP11180
Milk FractionWhey
Aminoacid Length 10
Molecular Weight 1066
FASTA Sequence Download
Gene Name DLAT
Gene ID 512723
Protein Existence Status Reviewed

Secondary Information

Protein Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.
PTMs Delipoylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Delipoylated at Lys-5 by SIRT4, delipoylation decreases the PHD complex activity
Bibliography Vijayakrishnan, S., Kelly, S. M., Gilbert, R. J., Callow, P., Bhella, D., Forsyth, T., Lindsay, J. G., & Byron, O. (2010). Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. Journal of molecular biology, 399(1), 71–93.