Primary Information |
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| BoMiProt ID | Bomi5100 |
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| Protein Name | Developmentally-regulated GTP-binding protein 2/Translation factor GTPase DRG2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q58D56 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001014865.1 |
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| Aminoacid Length | 364 |
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| Molecular Weight | 40749 |
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| FASTA Sequence |
Download |
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| Gene Name | DRG2 |
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| Gene ID | 507472 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | laryngeal cartilage |
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| Protein Function | Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. DRG2 plays an active role in regulating adipocyte differentiation, and thus participates in the development of obesity during exposure to a fat-rich diet. |
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| Biochemical Properties | DRG2 does not contain any of these domains and did not bind to any of the PIPs.DRG2 associates with membrane tubules by interacting with proteins on these membrane tubules in a PI4P-dependent manner. |
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| PTMs | Hydroxylation at C-3 of Lys-21 by JMJD7, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | The overexpression of DRG2 resulted in an increase in the expression of genes associated with fatty acid synthesis, including acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (Fasn), and a decrease in the expression of carnitine palmitoyltransferase 1 C (CPT1c; a mitochondrial enzyme responsible for lipid oxidation) and aquaporin-7. |
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| Bibliography | 1.Park BS, Im HL, Yoon NA, Tu TH, Park JW, Kim JG, Lee BJ. Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation. Biochem Biophys Res Commun. 2021 Nov 12;578:1-6. doi: 10.1016/j.bbrc.2021.08.081. Epub 2021 Aug 29. PMID: 34520979. 2.S. Guo, L.E. Stolz, S.M. Lemrow, J.D. York, SAC1-like domains of yeast SAC1, INP52,and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J.Biol. Chem. 274 (1999) 12990-12995. 3.B.D. Grant, J.G. Donaldson, Pathways and mechanisms of endocytic recycling. Nat.Rev. Mol. Cell Biol. 10 (2009) 597-608. |
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