Primary Information |
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| BoMiProt ID | Bomi5077 |
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| Protein Name | Deoxyhypusine synthase |
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| Organism | Bos taurus |
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| Uniprot ID | Q6EWQ6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001003657.1 |
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| Aminoacid Length | 369 |
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| Molecular Weight | 41029 |
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| FASTA Sequence |
Download |
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| Gene Name | DHPS |
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| Gene ID | 444988 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Deoxyhypusine synthase (DHS) first transfers the aminobutyl moiety of spermidine to a specific lysine residue of eIF5A, forming deoxyhypusine which is subsequently hydroxylated by deoxyhypusine hydroxylase (DOHH). |
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| Biochemical Properties | utilise NAD as cofactor |
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| PTMs | phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q6EWQ6|DHYS_BOVIN Deoxyhypusine synthase OS=Bos taurus OX=9913 GN=DHPS PE=2 SV=2
MEGPQEREVPAAALAAVLKHSSALPFETAQVRGYDFNRGVDYRALLEAFSTTGFQATNFG
RAVQQVNAMIEKKLEPLS*78EDEDQHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLV
QHNMVDVLVTTAGGVEEDFIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFE
DWLMPILDQMVLEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVLSPALTDGS
LGDMIFFHSYKNPGLVLDIVEDLKLINTQAIFAKRTGMIILGGGMVKHHIANANLMRNGA
DYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKVD
AFMPEKNED
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| Predicted Disorder Regions | 1-10, 77-91, 316-319, 362-368 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylated by PKC which has a possible regulation in the interaction with eIF5A precursor for hypusine synthesis. |
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| Bibliography | Kang KR, Kim JS, Chung SI, Park MH, Kim YW, Lim D, Lee SY. Deoxyhypusine synthase is phosphorylated by protein kinase C in vivo as well as in vitro. Exp Mol Med. 2002 Dec 31;34(6):489-95. doi: 10.1038/emm.2002.68. PMID: 12526092. |
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