Primary Information
BoMiProt ID	Bomi5076
Protein Name	Deoxyhypusine hydroxylase/Deoxyhypusine dioxygenase/Deoxyhypusine monooxygenase
Organism	Bos taurus
Uniprot ID	Q0VC53
Milk Fraction	Exosomes
Ref Sequence ID	NP_001069354.1
Aminoacid Length	303
Molecular Weight	33261
FASTA Sequence	Download
Gene Name	DOHH
Gene ID	526521
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	longissimus thoracis muscle
Protein Function	Deoxyhypusine hydroxylase (DOHH) is a fundamental enzyme catalyzing a unique posttranslational hypusination modification of eukaryotic translation initiation factor 5A (eIF5A) and is highly involved in the progression of several human diseases, including HIV-1 infection, cancer, malaria, and diabetes.
Biochemical Properties	DOHH comprises a pseudosymmetric arrangement of an N-terminal domain (DOHH-N, amino acids 1–151) and a C-terminal domain (DOHH-C, amino acids 152–302), each consisting of four HEAT repeats (α-hairpins) for a total of 16 α-helices.
PTMs	N-acetylation at Meth
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	137-152
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Guo Q, Zhang YC, Wang W, Wang YQ, Liu Y, Yang Z, Zhao MM, Feng N, Wang YH, Zhang XW, Yang H, Liu TT, Shi LY, Shi XM, Liu D, Tu PF, Zeng KW. Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. Pharmacol Res. 2022 Feb;176:106046. doi: 10.1016/j.phrs.2021.106046. Epub 2022 Jan 7. PMID: 35007708. 2.Close Z. Han, N. Sakai, L.H. Böttger, S. Klinke, J. Hauber, A.X. Trautwein, R. Hilgenfeld.Crystal structure of the peroxo-diiron(III) intermediate of deoxyhypusine hydroxylase, an oxygenase involved in hypusination Structure, 23 (2015), pp. 882-892.