Search by BoMiProt ID - Bomi5044

Primary Information

BoMiProt ID Bomi5044
Protein Name Dehydrogenase/reductase SDR family member 7B/short-chain dehydrogenase/reductase SDR family member 7B
Organism Bos taurus
Uniprot IDQ3T0R4
Milk FractionWhey
Ref Sequence ID NP_001030420.1
Aminoacid Length 325
Molecular Weight 35032
FASTA Sequence Download
Gene Name DHRS7B/SDR32C1
Gene ID 522283
Protein Existence Status reviewed

Secondary Information

Protein Function Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of steroids, oxysterols, bile acids, and retinoids in peripheral tissues, thereby controlling the local activation of their cognate receptors. 
Biochemical Properties A short chain dehydrogenase/reductase NcmD was proposed to catalyze the conversion of the hydroxyl group to ketone at the C-10 position. 
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-8, 315-325
DisProt Annotation
TM Helix Prediction 1TMH; (19-41)
Additional Comments  SDRs are considered as promising therapeutic targets, for example to treat estrogen-/androgen-dependent and corticosteroid-related diseases, whereas others are considered as anti-targets as their inhibition may lead to disturbances of endocrine functions, thereby contributing to the development and progression of diseases.
Bibliography 1.Beck KR, Kaserer T, Schuster D, Odermatt A. Virtual screening applications in short-chain dehydrogenase/reductase research. J Steroid Biochem Mol Biol. 2017 Jul;171:157-177. doi: 10.1016/j.jsbmb.2017.03.008. Epub 2017 Mar 9. PMID: 28286207; PMCID: PMC6831487.