Search by BoMiProt ID - Bomi5040

Primary Information

BoMiProt ID Bomi5040
Protein Name Dehydrogenase/reductase SDR family member 11/17-beta-hydroxysteroid dehydrogenase/3-beta-hydroxysteroid 3-dehydrogenase/Estradiol 17-beta-dehydrogenase/Short-chain dehydrogenase/reductase family 24C member 1
Organism Bos taurus
Uniprot IDQ3ZBV9
Milk FractionWhey,MFGM
Ref Sequence ID NP_001030260.1
Aminoacid Length 255
Molecular Weight 27811
FASTA Sequence Download
Gene Name DHRS11/SDR24C1
Gene ID 510264
Protein Existence Status Reviewed

Secondary Information

Protein Function Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites.
Significance in milk biosynthesis of active steroid hormones such as progesterone, mineralo- and gluco-corticoids, estrogens, and androgens.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 211-217, 252-254
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Endo, S., Morikawa, Y., Kudo, Y., Suenami, K., Matsunaga, T., Ikari, A., & Hara, A. (2020). Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids. The Journal of steroid biochemistry and molecular biology, 199, 105586.