Search by BoMiProt ID - Bomi4994

Primary Information

BoMiProt ID Bomi4994
Protein Name Cytochrome P450 2U1/Long-chain fatty acid omega-monooxygenase
Organism Bos taurus
Uniprot IDQ0IIF9
Milk FractionWhey
Ref Sequence ID NP_001069518.1
Aminoacid Length 543
Molecular Weight 61997
FASTA Sequence Download
Gene Name CYP2U1
Gene ID 535227
Protein Existence Status reviewed

Secondary Information

Protein Function A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates.Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients
Biochemical Properties CYPs are a superfamily of enzymes with related catalysis to endogenous and exogenous bioactive substances, including xenobiotic metabolism, drugs, and some endogenous substances metabolism which activate cells and stimulate cell signaling pathways, such as arachidonic acid metabolism, steroid metabolism, fatty acid metabolism. Catalyses the following reaction- ω-methyl-long-chain fatty acid + O2 + reduced [NADPH—hemoprotein reductase] = an ω-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH—hemoprotein reductase]
PTMs Phosphorylation at Ser/Tyr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (1-12)
DisProt Annotation
TM Helix Prediction 2TMHs; (34-52) and (59-77)
Additional Comments Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues and an insert of about 20 amino acids containing 5 arginine residues after the transmembrane helix.
Bibliography 1.Dhers L, Ducassou L, Boucher JL, Mansuy D. Cytochrome P450 2U1, a very peculiar member of the human P450s family. Cell Mol Life Sci. 2017 May;74(10):1859-1869. doi: 10.1007/s00018-016-2443-3. Epub 2017 Jan 12. PMID: 28083596. 2.Luo B, Chen C, Wu X, Yan D, Chen F, Yu X, Yuan J. Cytochrome P450 2U1 Is a Novel Independent Prognostic Biomarker in Breast Cancer Patients. Front Oncol. 2020 Aug 5;10:1379. doi: 10.3389/fonc.2020.01379. PMID: 32850442; PMCID: PMC7419690.