Primary Information |
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| BoMiProt ID | Bomi4993 |
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| Protein Name | Cytochrome P450 26B1 |
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| Organism | Bos taurus |
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| Uniprot ID | E1BHJ4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001179722.1 |
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| Aminoacid Length | 512 |
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| Molecular Weight | 57414 |
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| FASTA Sequence |
Download |
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| Gene Name | CYP26B1 |
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| Gene ID | 540868 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | involved at several steps in the biosynthesis of Ras and CYPs consist of a superfamily of
heme-containing monooxygenases that are associated with the metabolism of various substrates, including drugs, environmental pollutants, endogenous substrates, and have broad overlapping specificity. |
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| Biochemical Properties | It shows specific 4-hydroxylase activity present in zebrafish, mouse and humans. |
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| Significance in milk | primarily responsible for the degradation of the active forms of vitamin A.Responsible for tight regulation of vitamin A necessary during pregnancy in cattle. |
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| PTMs | N-acetylation at Methionine and N-Linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (7-29) |
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| Significance of PTMs | Contains N-linked glycan gives resistant to endoglycosydase H. |
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| Additional Comments | Exogenous retinoic acid and cytochrome P450 26B1 inhibitor modulate meiosis-associated genes expression in canine testis, an in vitro model |
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| Bibliography | 1.Kasimanickam V, Kasimanickam R. Exogenous retinoic acid and cytochrome P450 26B1 inhibitor modulate meiosis-associated genes expression in canine testis, an in vitro model. Reprod Domest Anim. 2014 Apr;49(2):315-23. doi: 10.1111/rda.12276. Epub 2014 Jan 27. PMID: 24467691. 2.Karlsson M, Strid Å, Sirsjö A, Eriksson LA. Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1). J Chem Theory Comput. 2008 Jun;4(6):1021-7. doi: 10.1021/ct800033x. PMID: 26621242. 3.Marill, Julie; Idres, Nadia; Capron, Claude; Nguyen, Eric; Chabot, Guy (2003). Retinoic Acid Metabolism and Mechanism of Action: A Review. Current Drug Metabolism, 4(1), 1–10.doi:10.2174/1389200033336900. 4.] Danielson, P.B. (2002) Current Drug Metabolism, 3(6),
561-597. 4.Kuhn MJ, Putman AK, Sordillo LM. Widespread basal cytochrome P450 expression in extrahepatic bovine tissues and isolated cells. J Dairy Sci. 2020 Jan;103(1):625-637. doi: 10.3168/jds.2019-17071. Epub 2019 Oct 31. PMID: 31677841. |
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