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Primary Information | |
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| BoMiProt ID | Bomi4989 |
| Protein Name | Cytochrome c oxidase subunit 7A1, mitochondrial/Cytochrome c oxidase subunit VIIIc/Cytochrome c oxidase subunit VIIa-heart |
| Organism | Bos taurus |
| Uniprot ID | P07470 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_788847.1 |
| Aminoacid Length | 80 |
| Molecular Weight | 9063 |
| FASTA Sequence | Download |
| Gene Name | COX7A1 |
| Gene ID | 338086 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | tongue muscle |
| Protein Function | COX7A1 as a novel gene that might play a crucial role in the etiology of lung adenocarcinoma and can serve as a biomarker for lung cancer disease progression. |
| Biochemical Properties | The utilization of oxygen by the mitochondria to generate energy is under the control of cytochrome c oxidase (complex IV or Cox) which consists of 13 subunits (10 encoded in the nuclear genome, 3 encoded in the mitochondrial genome).It has been proposed that Cox is the rate-limiting enzyme of the electron transport chain (ETC) and studies have revealed six isoforms of Cox subunits that are tissue specific and that potentially regulate energy production. |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
| SCOP | Class : All alpha proteins Fold : Single transmembrane helix Superfamily : Mitochondrial cytochrome c oxidase subunit VIIa Family : Mitochondrial cytochrome c oxidase subunit VIIa Domain Name : 1V54 J:1-58 |
| CATH | Matched CATH superfamily 4.10.91.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | 1TMH; (51-73) |
| PDB ID | 1OCC, 1OCO, 1OCR, 1OCZ, 1V54, 1V55, 2DYR, 2DYS, 2EIJ, 2EIK, 2EIL, 2EIM, 2EIN, 2OCC, 2Y69, 2YBB, 2ZXW, 3ABK, 3ABL, 3ABM, 3AG1, 3AG2, 3AG3, 3AG4, 3AGN, 3ASO,3WG7, 3X2Q, 5B1A, 5B1B, 5B3S, 5GPN, 5IY5, 5LUF, 5W97, 5WAU, 5X19, 5X1B, 5X1F, 5XDQ, 5XDX, 5XTH, 5XTI, 5Z84, 5Z85, 5Z86, 5ZCO, 5ZCP, 5ZCQ, 6J8M, 6JUW, 6JY3, 6JY4, 6NKN, 6NMF, 6NMP, 7COH, 7CP5, 7D5W, 7D5X, 7EV7, |
| Additional Comments | Deletion of the Cox7a1 isoform results in reduced muscle bioenergetics and hindlimb capillarity, helping to explain the observed impairment of muscle structure and function. Overexpression of COX7A1 in human lung cancer cells led to inhibition of cell proliferation and increase in cell death via apoptosis. |
| Bibliography | 1.Lee I, Hüttemann M, Liu J, Grossman LI, Malek MH. Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation. J Physiol. 2012 Oct 15;590(20):5231-43. doi: 10.1113/jphysiol.2012.239707. Epub 2012 Aug 6. PMID: 22869013; PMCID: PMC3497574. 2.Mishra N, Timilsina U, Ghimire D, Dubey RC, Gaur R. Downregulation of cytochrome c oxidase subunit 7A1 expression is important in enhancing cell proliferation in adenocarcinoma cells. Biochem Biophys Res Commun. 2017 Jan 22;482(4):713-719. doi: 10.1016/j.bbrc.2016.11.100. Epub 2016 Nov 17. PMID: 27866983. 3.Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation.Hüttemann M, Helling S, Sanderson TH, Sinkler C, Samavati L, Mahapatra G, Varughese A, Lu G, Liu J, Ramzan R, Vogt S, Grossman LI, Doan JW, Marcus K, Lee I.Biochim Biophys Acta. 2012 Apr; 1817(4):598-609. 4.An intragenic suppressor in the cytochrome c oxidase I gene of mouse mitochondrial DNA.Acín-Pérez R, Bayona-Bafaluy MP, Bueno M, Machicado C, Fernández-Silva P, Pérez-Martos A, Montoya J, López-Pérez MJ, Sancho J, Enríquez JA.Hum Mol Genet. 2003 Feb 1; 12(3):329-39. 5.Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Hüttemann M, Helling S, Sanderson TH, Sinkler C, Samavati L, Mahapatra G, Varughese A, Lu G, Liu J, Ramzan R, Vogt S, Grossman LI, Doan JW, Marcus K, Lee I.Biochim Biophys Acta. 2012 Apr; 1817(4):598-609. |