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Primary Information | |
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| BoMiProt ID | Bomi4988 |
| Protein Name | Cytochrome c oxidase subunit 6B1/Cytochrome c oxidase polypeptide VII/Cytochrome c oxidase subunit AED |
| Organism | Bos taurus |
| Uniprot ID | P00429 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_788848.1 |
| Aminoacid Length | 86 |
| Molecular Weight | 10156 |
| FASTA Sequence | Download |
| Gene Name | COX6B1 |
| Gene ID | 100270792 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Protein Function | Cox6b1 is involved in regulation of mitochondrial function by promoting the formation of SC(supercomplexes), suggesting that Cox6b1 contributes to the anti-aging effects of CR(Calorie restriction). |
| PTMs | N-acetylalanine,Disulfide bond formation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | na |
| SCOP | Class : All alpha proteins Fold : Cytochrome c oxidase subunit h Superfamily : Cytochrome c oxidase subunit h Family : Cytochrome c oxidase subunit h Domain Name : 1V54 H:7-85 |
| CATH | Matched CATH superfamily 1.10.10.140 |
| Predicted Disorder Regions | 1-28, 74-86 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1OCC, 1OCO, 1OCR, 1OCZ, 1V54, 1V55, 2DYR, 2DYS, 2EIJ, 2EIK, 2EIL, 2EIM, 2EIN, 2OCC, 2Y69, 2YBB, 2ZXW, 3ABK, 3ABL, 3ABM, 3AG1, 3AG2, 3AG3, 3AG4, 3AGN, 3ASO,3WG7, 3X2Q, 5B1A, 5B1B, 5B3S, 5GPN, 5IY5, 5LUF, 5W97, 5WAU, 5X19, 5X1B, 5X1F, 5XDQ, 5XDX, 5XTH, 5XTI, 5Z84, 5Z85, 5Z86, 5ZCO, 5ZCP, 5ZCQ, 6J8M, 6JUW, 6JY3, 6JY4, 6NKN, 6NMF, 6NMP, 7COH, 7CP5, 7D5W, 7D5X, 7EV7, |
| Bibliography | 1.Kim SE, Mori R, Komatsu T, Chiba T, Hayashi H, Park S, Sugawa MD, Dencher NA, Shimokawa I. Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction. Age (Dordr). 2015 Jun;37(3):9787. doi: 10.1007/s11357-015-9787-8. Epub 2015 May 1. PMID: 25929654; PMCID: PMC4416092. 2.Tanaka M, Yasunobu KT, Wei YH, King TE. The complete amino acid sequence of bovine heart cytochrome oxidase subunit VI. J Biol Chem. 1981 May 25;256(10):4832-7. PMID: 6262305. |