Search by BoMiProt ID - Bomi4986

Primary Information

BoMiProt ID Bomi4986
Protein Name Cytochrome c oxidase subunit 5A, mitochondrial/Cytochrome c oxidase polypeptide Va
Organism Bos taurus
Uniprot IDP00426
Milk FractionWhey
Ref Sequence ID NP_001002891.1
Aminoacid Length 152
Molecular Weight 16735
FASTA Sequence Download
Gene Name COX5A
Gene ID 444878
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells corpus luteum
Protein Function Cytochrome c oxidase subunit 5A (COX5A) is a nuclear-encoded subunit of the terminal oxidase involved in mitochondrial electron transport.COX5A appears to play a key role in modulating the physiological activity of COX and involve in energy metabolism.
Biochemical Properties During the assembly of COX in the mammalian cells, COX1 is first integrated into the inner membrane; this is followed by the formation of the COX4-COX5A heterodimer.COX5A binds indirectly to COX1 via the matrix domain of COX4.COX5A binds specifically to 3, 5-diiodothyronine, abrogating the allosteric ATP inhibition of COX.
PTMs N6-acetylation at Lys,Phosphorylation at Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
SCOP Class : All alpha proteins
Fold : alpha-alpha superhelix
Superfamily : Cytochrome c oxidase subunit E
Family : Cytochrome c oxidase subunit E
Domain Name : 1V54 E:5-109

CATH Matched CATH superfamily
Predicted Disorder Regions 1-3, 21-34, 146-152
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1OCC, 1OCO, 1OCR, 1OCZ, 1V54, 1V55, 2DYR, 2DYS, 2EIJ, 2EIK, 2EIL, 2EIM, 2EIN, 2OCC, 2Y69, 2YBB, 2ZXW, 3ABK, 3ABL, 3ABM, 3AG1, 3AG2, 3AG3, 3AG4, 3AGN, 3ASO,3WG7, 3X2Q, 5B1A, 5B1B, 5B3S, 5GPN, 5IY5, 5LUF, 5W97, 5WAU, 5X19, 5X1B, 5X1F, 5XDQ, 5XDX, 5XTH, 5XTI, 5Z84, 5Z85, 5Z86, 5ZCO, 5ZCP, 5ZCQ, 6J8M, 6JUW, 6JY3, 6JY4, 6NKN, 6NMF, 6NMP, 7COH, 7CP5, 7D5W, 7D5X, 7EV7,
Additional Comments Abnormal expression of COX5A significantly affects COX function, thereby causing mitochondrial dysfunction in skeletal muscle, pulmonary arterial hypertension, lactic academia, and failure to thrive.
Bibliography 1.Zhang P, Chen Z, Lu D, Wu Y, Fan M, Qian J, Ge J. Overexpression of COX5A protects H9c2 cells against doxorubicin-induced cardiotoxicity. Biochem Biophys Res Commun. 2020 Mar 26;524(1):43-49. doi: 10.1016/j.bbrc.2020.01.013. Epub 2020 Jan 22. PMID: 31980176. 2.Y.Y. Gong, Y.Y. Liu, J. Li, L. Su, S. Yu, X.N. Zhu, X.P. Cao, H.P. Xiao Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats PLoS One, 9 (2014), Article e113784, 10.1371/journal.pone.0113784. 3.F. Baertling, F. Al-Murshedi, L. Sanchez-Caballero, K. Al-Senaidi, N.P. Joshi, H. Venselaar, M.A. van den Brand, L.G. Nijtmans, R.J. Rodenburg Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive Hum. Mutat., 38 (2017), pp. 692-703, 10.1002/humu.23210. 4.L. Stiburek, K. Vesela, H. Hansikova, P. Pecina, M. Tesarova, L. Cerna, J. Houstek, J. Zeman.Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1.Biochem. J., 392 (2005), pp. 625-632, 10.1042/BJ20050807. 5.S. Arnold, F. Goglia, B. Kadenbach.3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.Eur. J. Biochem., 252 (1998), pp. 325-330, 10.1046/j.1432-1327.1998.2520325.x.