Primary Information |
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| BoMiProt ID | Bomi4975 |
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| Protein Name | Cysteine-rich secretory protein LCCL domain-containing 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A6QLZ7 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001093769.1 |
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| Aminoacid Length | 496 |
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| Molecular Weight | 55581 |
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| FASTA Sequence |
Download |
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| Gene Name | CRISPLD2 |
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| Gene ID | 505329 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | A lipopolysaccharide-binding serum protein thought to have an anti-inflammatory function.Take part in extra cellular matrix assembly,Binds to heparin, dermatan sulfate and chondroitin sulfate |
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| Biochemical Properties | two LCCL-domains of human CRISPLD2 protein, a lipopolysaccharide-binding serum protein involved in defense against endotoxin shock, have higher affinity for the lipid A, the toxic moiety of lipopolysaccharides than for lipopolysaccharide |
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| Significance in milk | immune function.It can bind to LPS, a major structural component of Gram-negative bacterial cell walls, and is thought to have an anti-inflammatory function.only present in colostrum |
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| PTMs | N linked glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QLZ7|CRLD2_BOVIN Cysteine-rich secretory protein LCCL domain-containing 2 OS=Bos taurus OX=9913 GN=CRISPLD2 PE=2 SV=1
MSCVLTGVVPLGLVLLLCGAQGFFLPN*27VTQLEKLLSKYQGDQPHSRTRRAISRADREEIL
TLHNKLRGQVSPPASNMEYMTWDEELEKSAVAWARECIWEHGPTSLLVSIGQNLAVHWGR
PRSPGSHVQSWYDEVKDYTYPYPHECNPWCPERCSGPMCTHYTQIVWATTNRIGCAVNTC
PRMNVWGDVWENAVYLVCNYFPKGNWIGEAPYKTGQPCSECPGKYRGGCKNNLCYQETYG
QETETDDMNEVEAAPIPDEKHVWVTPRVIKPKKPKKDSPVNYMTQVVKCDTKMKDKCKGS
TCNRYQCPAGCLHSGAKIFGTLFYESASSICRAAIHYGILDDRGGLVDVTRNGKVPFFVK
SERNGVQSLSKYKASSSFTVSKVKVQDLDCYTTVAQLCPYEKPGTHCPRVRCPAHCKDEP
SYWAPVFGSNIYADTSSICKTAVHAGVIRNESGGYVDVMPVDKKKTYVASLRNGVQSESL
RTPRDGKAFRIFAVRQ
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| Predicted Disorder Regions | 3 predicted disordered segments;(41-50),(247-253),(265-281) |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (7-25) |
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| Bibliography | 1.Cheng, Z., Oguejiofor, C. F., Swangchan-Uthai, T., Carr, S., & Wathes, D. C. (2015). Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows. Animals : an open access journal from MDPI, 5(3), 748–773. https://doi.org/10.3390/ani5030382 2.Vásárhelyi V, Trexler M, Patthy L. Both LCCL-domains of human CRISPLD2 have high affinity for lipid A. Biochimie. 2014 Feb;97:66-71. doi: 10.1016/j.biochi.2013.09.021. Epub 2013 Oct 1. PMID: 24090571. |
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