Search by BoMiProt ID - Bomi4965

Primary Information

BoMiProt ID Bomi4965
Protein Name Cystathionine gamma-lyase/Cysteine-protein sulfhydrase/Gamma-cystathionase
Organism Bos taurus
Uniprot IDQ58DW2
Milk FractionExosomes
Ref Sequence ID NP_001019738.1
Aminoacid Length 405
Molecular Weight 44406
FASTA Sequence Download
Gene Name CTH
Gene ID 539159
Protein Existence Status Reviewed

Secondary Information

Protein Function Cystathionine gamma-lyase (CSE) catalyzes hydrogen sulfide (H2S) synthesis by the conversion of cystathionine to L-cysteine, yielding pyruvate, ammonia, and H2S. Cystathionine γ-lyase (CSE) promotes vascular NO signaling by producing hydrogen sulfide (H2S) and by maintaining the ratio of reduced-to-oxidized intracellular glutathione (GSH/GSSG) through l-cysteine production.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-13, 46-59, 395-405
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 Apr;40:101827. doi: 10.1016/j.redox.2020.101827. Epub 2020 Dec 8. PMID: 33485059; PMCID: PMC7823052. 2.Ozluk E, Patel S, Coppola D, Ghali G, Cotelingam JD, Kevil CG, Shackelford RE. Cystathionine Gamma-Lyase Is Increased in Testicular Seminomas, Embryonal, and Yolk Sac Tumors. Anticancer Res. 2021 Sep;41(9):4211-4214. doi: 10.21873/anticanres.15225. Epub 2021 Sep 1. PMID: 34475040; PMCID: PMC8667692.