Primary Information
BoMiProt ID	Bomi4962
Protein Name	Cyclin-dependent-like kinase 5/Cell division protein kinase 5 /Proline-directed protein kinase 33 kDa subunit/PDPK/Serine/threonine-protein kinase PSSALRE/Tau protein kinase II catalytic subunit/TPKII catalytic subunit
Organism	Bos taurus
Uniprot ID	Q02399
Milk Fraction	Whey
Ref Sequence ID	NP_776442.1
Aminoacid Length	292
Molecular Weight	33288
FASTA Sequence	Download
Gene Name	CDK5/CDKN5
Gene ID	281066
Protein Existence Status	reviewed
Secondary Information
Protein Function	This is required for pain signaling in human sensory neurons and mouse models.
Biochemical Properties	CDKL5 interacts with calcium/calmodulin-dependent protein kinase II α (CaMKIIα) to control outgrowth and transient receptor potential cation channel subfamily V member 1 (TRPV1)-dependent signaling
PTMs	Acetylation at Lys and Phosphorylation at Ser/Thr
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q02399|CDK5_BOVIN Cyclin-dependent-like kinase 5 OS=Bos taurus OX=9913 GN=CDK5 PE=1 SV=2 MQKYEKLEKIGEGTY*15GT*17VFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH KNIVRLHDVLHS*72DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS*159AEVVTLWYRPPDVLFGAKLYS TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYP MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	O-GlcNAc modification determined the conformation of critical T-loop domain on CDK5 and further influenced the CDK5 stability.
Additional Comments	Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of CDK5.
Bibliography	1.Wu J, Tan Z, Li H, Lin M, Jiang Y, Liang L, Ma Q, Gou J, Ning L, Li X, Guan F. Melatonin reduces proliferation and promotes apoptosis of bladder cancer cells by suppressing O-GlcNAcylation of cyclin-dependent-like kinase 5. J Pineal Res. 2021 Oct;71(3):e12765. doi: 10.1111/jpi.12765. Epub 2021 Sep 18. PMID: 34487576. 2.La Montanara P, Hervera A, Baltussen LL, Hutson TH, Palmisano I, De Virgiliis F, Kong G, Chadwick J, Gao Y, Bartus K, Majid QA, Gorgoraptis N, Wong K, Downs J, Pizzorusso T, Ultanir SK, Leonard H, Yu H, Millar DS, Istvan N, Mazarakis ND, Di Giovanni S. Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med. 2020 Jul 8;12(551):eaax4846. doi: 10.1126/scitranslmed.aax4846. PMID: 32641489; PMCID: PMC7116442.