Search by BoMiProt ID - Bomi4945


Primary Information

BoMiProt ID Bomi4945
Protein Name Cyclic AMP-dependent transcription factor ATF-1
Organism Bos taurus
Uniprot IDQ08DA8
Milk FractionWhey
Ref Sequence ID NP_001068757.1
Aminoacid Length 270
Molecular Weight 29261
FASTA Sequence Download
Gene Name ATF1
Gene ID 506967
Protein Existence Status reviewed

Secondary Information

Protein Function This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes.Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Biochemical Properties This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters.
PTMs  Phosphoprotein, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q08DA8|ATF1_BOVIN Cyclic AMP-dependent transcription factor ATF-1 OS=Bos taurus OX=9913 GN=ATF1 PE=2 SV=1 MEDSHKSNTSETAPQSGSTVQAAHISHIAQQVSSLSESEESQDSSDSIGSSQKTHGILAR RPS*63YRKILKDLSSEDIRGRKGDGENPGVSAVTSMSVPTPIYQTSTGQYIAIAPNGALQLA SPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQI RTTPSATSLPQTVVMTS*197PVTLTSQTSKTDDPQLKREIRLMKNREAARECRRKKKEYVKCL ENRVAVLENQNKTLIEELKTLKDLYSNKSV
Predicted Disorder Regions 1 disordered segment ; (1-231)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylated at Ser-197 by HIPK2 in response to genotoxic stress.CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities.
Bibliography Kingsley-Kallesen ML, Kelly D, Rizzino A. Transcriptional regulation of the transforming growth factor-beta2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein. J Biol Chem. 1999 Nov 26;274(48):34020-8. doi: 10.1074/jbc.274.48.34020. PMID: 10567368.