Search by BoMiProt ID - Bomi4904


Primary Information

BoMiProt ID Bomi4904
Protein Name Creatine kinase B-type
Organism Bos taurus
Uniprot IDQ5EA61
Milk FractionWhey
Ref Sequence ID NP_001015613.1
Aminoacid Length 381
Molecular Weight 42719
FASTA Sequence Download
Gene Name CKB
Gene ID 516210
Protein Existence Status reviewed

Secondary Information

Presence in other biological fluids/tissue/cells expressed in brain and smooth muscle, including vascular and uterine tissue.
Protein Function BCK is co-localizing with and fueling the gastric H+/K+-ATPase pump at the apical membrane,role in synaptic transmission at the synaptic terminal and the membranes of the tubulovesicular system.
Biochemical Properties Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).
Significance in milk Probably maintaing creatinine level.Creatinin is secreted by the mammary gland during lactation and has been shown to be absolutely required for normal brain development and brain function
PTMs Nitration,Phosphorylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q5EA61|KCRB_BOVIN Creatine kinase B-type OS=Bos taurus OX=9913 GN=CKB PE=1 SV=1 MPFS*4NSHNTLKLRFPAEDEFPDLSGHNNHMAKVLT*35PELYAELRAKSTPSGFTVDDVIQTG VDNPGHPYIMTVGCVAGDEESYDVFKELFDPIIEDRHGGYKPTDEHKTDLNPDNLQGGDD LDPNY*125VLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMT EAEQQQLIDDHFLFDKPVS*199PLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISM QKGGNMKEVFTRFCNGLTQIETLFKSKNY*269EFMWNPHLGYILTCPSNLGTGLRAGVHIKLP HLGKHEKFPEVLKRLRLQKRGT*322GGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLL IEMEQRLEQGQAIDDLMPAQK
CATH Matched CATH superfamily
1.10.135.10
3.30.590.10
Predicted Disorder Regions 3 disordered segments; (12-21), (97-122), (372-381)
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 4Q2R,
Bibliography 1.Schlattner, U., Klaus, A., Ramirez Rios, S. et al. Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites. Amino Acids 48, 1751–1774 (2016). https://doi.org/10.1007/s00726-016-2267-3 2.Schlattner U, Klaus A, Ramirez Rios S, Guzun R, Kay L, Tokarska-Schlattner M. Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites. Amino Acids. 2016 Aug;48(8):1751-74. doi: 10.1007/s00726-016-2267-3. Epub 2016 Jun 18. PMID: 27318991. 3.Wallimann, T., Tokarska-Schlattner, M., & Schlattner, U. (2011). The creatine kinase system and pleiotropic effects of creatine. Amino acids, 40(5), 1271–1296. https://doi.org/10.1007/s00726-011-0877-3