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Primary Information | |
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| BoMiProt ID | Bomi4904 |
| Protein Name | Creatine kinase B-type |
| Organism | Bos taurus |
| Uniprot ID | Q5EA61 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001015613.1 |
| Aminoacid Length | 381 |
| Molecular Weight | 42719 |
| FASTA Sequence | Download |
| Gene Name | CKB |
| Gene ID | 516210 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | expressed in brain and smooth muscle, including vascular and uterine tissue. |
| Protein Function | BCK is co-localizing with and fueling the gastric H+/K+-ATPase pump at the apical membrane,role in synaptic transmission at the synaptic terminal and the membranes of the tubulovesicular system. |
| Biochemical Properties | Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). |
| Significance in milk | Probably maintaing creatinine level.Creatinin is secreted by the mammary gland during lactation and has been shown to be absolutely required for normal brain development and brain function |
| PTMs | Nitration,Phosphorylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q5EA61|KCRB_BOVIN Creatine kinase B-type OS=Bos taurus OX=9913 GN=CKB PE=1 SV=1 MPFS*4NSHNTLKLRFPAEDEFPDLSGHNNHMAKVLT*35PELYAELRAKSTPSGFTVDDVIQTG VDNPGHPYIMTVGCVAGDEESYDVFKELFDPIIEDRHGGYKPTDEHKTDLNPDNLQGGDD LDPNY*125VLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMT EAEQQQLIDDHFLFDKPVS*199PLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISM QKGGNMKEVFTRFCNGLTQIETLFKSKNY*269EFMWNPHLGYILTCPSNLGTGLRAGVHIKLP HLGKHEKFPEVLKRLRLQKRGT*322GGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLL IEMEQRLEQGQAIDDLMPAQK |
| CATH | Matched CATH superfamily 1.10.135.10 3.30.590.10 |
| Predicted Disorder Regions | 3 disordered segments; (12-21), (97-122), (372-381) |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 4Q2R, |
| Bibliography | 1.Schlattner, U., Klaus, A., Ramirez Rios, S. et al. Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites. Amino Acids 48, 1751–1774 (2016). https://doi.org/10.1007/s00726-016-2267-3 2.Schlattner U, Klaus A, Ramirez Rios S, Guzun R, Kay L, Tokarska-Schlattner M. Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites. Amino Acids. 2016 Aug;48(8):1751-74. doi: 10.1007/s00726-016-2267-3. Epub 2016 Jun 18. PMID: 27318991. 3.Wallimann, T., Tokarska-Schlattner, M., & Schlattner, U. (2011). The creatine kinase system and pleiotropic effects of creatine. Amino acids, 40(5), 1271–1296. https://doi.org/10.1007/s00726-011-0877-3 |