Search by BoMiProt ID - Bomi4903

Primary Information

BoMiProt ID Bomi4903
Protein Name Craniofacial development protein 2/p97 bucentaur protein
Organism Bos taurus
Uniprot IDO02751
Milk FractionWhey
Ref Sequence ID NP_777225.1
Aminoacid Length 592
Molecular Weight 66325
FASTA Sequence Download
Gene Name CFDP2/BCNT
Gene ID 286876
Protein Existence Status reviewed

Secondary Information

Protein Function CFDP2,is the 1st identified member of BCNT protein superfamily,discovered in bovine brain,plays roles in chromatin organization.The Drosophila BCNT ortholog, called YETI,is essential for proper fly development .
Biochemical Properties It consisted of an acidic N-terminal region, a retrotransposon-derived 325-amino acid region (the RTE domain) and of two 40-amino acid intrarepeat (IR) units. The RTE domain was 72 % identical to that of a ruminant specific retrotransposon, called Bov-B LINE. The ~175-amino acid N-terminal portion of the three BCNT-related proteins is acidic as a whole but contains several arginine/lysine-rich elements, including a putative nuclear targeting motif of Arg-Lys-Arg-Lys (~61–64th).
PTMs Phosphorylation,Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-229, 466-475, 504-511, 530-574
DisProt Annotation
TM Helix Prediction no TM helices
Significance of PTMs phosphoproteins potentially phosphorylated in vitro on serine residues by the casein kinase II. two phosphorylated serine residues in human BCNT, Ser-116 in the N-terminal region and Ser-250 in the C-terminal region.Human and bovine BCNTs were found to be substrates for in vitro acetylation by the co-transcriptional activator CBP/p300, resulting in the acetylation of at least 15 lysine residues
Additional Comments Expressed in liver and lung with higher expression in brain.
Bibliography 1.Messina G, Celauro E, Atterrato MT, Giordano E, Iwashita S, Dimitri P. The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function. Chromosoma. 2015 Jun;124(2):153-62. doi: 10.1007/s00412-014-0503-8. Epub 2014 Dec 31. PMID: 25547403.