Primary Information |
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BoMiProt ID | Bomi4893 |
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Protein Name | COUP (chicken ovalbumin upstream promoter)transcription factor 1 |
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Organism | Bos taurus |
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Uniprot ID | Q9TTR8 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_786998.1 |
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Aminoacid Length | 424 |
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Molecular Weight | 46284 |
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FASTA Sequence |
Download |
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Gene Name | NR2F1 |
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Gene ID | 327684 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | It binds to the ovalbumin promoter and, in conjunction with a second protein (S300-II), stimulates initiation of transcription. |
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Biochemical Properties | Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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Predicted Disorder Regions | 3 disordered segments; (1-5), (28-41), (185-195) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | Insulin stimulation of these cells increased NR2F2 expression levels and promoted cell invasion and migration accompanied by alterations in EMT-related molecular markers. |
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Bibliography | Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW. COUP transcription factor is a member of the steroid receptor superfamily. Nature. 1989 Jul 13;340(6229):163-6. doi: 10.1038/340163a0. PMID: 2739739. |