Search by BoMiProt ID - Bomi4893

Primary Information

BoMiProt ID Bomi4893
Protein Name COUP (chicken ovalbumin upstream promoter)transcription factor 1
Organism Bos taurus
Uniprot IDQ9TTR8
Milk FractionWhey
Ref Sequence ID NP_786998.1
Aminoacid Length 424
Molecular Weight 46284
FASTA Sequence Download
Gene Name NR2F1
Gene ID 327684
Protein Existence Status reviewed

Secondary Information

Protein Function It binds to the ovalbumin promoter and, in conjunction with a second protein (S300-II), stimulates initiation of transcription.
Biochemical Properties Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 3 disordered segments; (1-5), (28-41), (185-195)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Insulin stimulation of these cells increased NR2F2 expression levels and promoted cell invasion and migration accompanied by alterations in EMT-related molecular markers.
Bibliography Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW. COUP transcription factor is a member of the steroid receptor superfamily. Nature. 1989 Jul 13;340(6229):163-6. doi: 10.1038/340163a0. PMID: 2739739.