Primary Information |
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| BoMiProt ID | Bomi4893 |
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| Protein Name | COUP (chicken ovalbumin upstream promoter)transcription factor 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q9TTR8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_786998.1 |
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| Aminoacid Length | 424 |
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| Molecular Weight | 46284 |
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| FASTA Sequence |
Download |
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| Gene Name | NR2F1 |
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| Gene ID | 327684 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | It binds to the ovalbumin promoter and, in conjunction with a second protein (S300-II), stimulates initiation of transcription. |
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| Biochemical Properties | Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 3 disordered segments; (1-5), (28-41), (185-195) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Insulin stimulation of these cells increased NR2F2 expression levels and promoted cell invasion and migration accompanied by alterations in EMT-related molecular markers. |
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| Bibliography | Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW. COUP transcription factor is a member of the steroid receptor superfamily. Nature. 1989 Jul 13;340(6229):163-6. doi: 10.1038/340163a0. PMID: 2739739. |
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