Search by BoMiProt ID - Bomi4878

Primary Information

BoMiProt ID Bomi4878
Protein Name COP9 signalosome complex subunit 4
Organism Bos taurus
Uniprot IDQ3SZA0
Milk FractionExosomes,MFGM
Ref Sequence ID NP_001029866.1
Aminoacid Length 406
Molecular Weight 46285
FASTA Sequence Download
Gene Name COPS4
Gene ID 540223
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells spermatid
Protein Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes
Biochemical Properties The complex is composed of eight subunits, CSN1-CSN8. Six (CSN1-CSN4, CSN7 and CSN8) contain a PCI (Proteasome, COP9 signalosome and eukaryotic initiation factor 3, eIF3) domain, and two (CSN5 and CSN6) contain a MPN (Mpr1p-Pad1p-N-terminal) domain2. In Arabidopsis, the PCI domain-containing subunits are encoded by single copy genes, while the MPN domain-containing subunits are each encoded by two highly homologous genes. 
PTMs N-acetylation at Ala
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Pacurar DI, Pacurar ML, Lakehal A, Pacurar AM, Ranjan A, Bellini C. The Arabidopsis Cop9 signalosome subunit 4 (CNS4) is involved in adventitious root formation. Sci Rep. 2017 Apr 4;7(1):628. doi: 10.1038/s41598-017-00744-1. Erratum in: Sci Rep. 2017 Jul 20;7(1):6435. PMID: 28377589; PMCID: PMC5429640. 2.Oron E, Mannervik M, Rencus S, Harari-Steinberg O, Neuman-Silberberg S, Segal D, Chamovitz DA. COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. Development. 2002 Oct;129(19):4399-409. doi: 10.1242/dev.129.19.4399. PMID: 12223399. 3.Kotiguda GG, et al. The organization of a CSN5-containing subcomplex of the COP9 signalosome. J. Biol. Chem. 2012;287:42031–42041. doi: 10.1074/jbc.M112.387977.