Search by BoMiProt ID - Bomi4871

Primary Information

BoMiProt ID Bomi4871
Protein Name Contactin-1/Neural cell surface protein F3
Organism Bos taurus
Uniprot IDQ28106
Milk FractionWhey
Ref Sequence ID NP_776705.1
Aminoacid Length 1018
Molecular Weight 113385
FASTA Sequence Download
Gene Name CNTN1
Gene ID 281705
Protein Existence Status Reviewed

Secondary Information

Protein Function Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1.
Biochemical Properties CNTN1 and CNTN2 have been reported to mediate interaction with the glycopeptide CD24 modulating cell adhesion and neurite outgrowth of cerebellar neurons
PTMs Glycosylation, Disulphide bond
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation 		>sp|Q28106|CNTN1_BOVIN Contactin-1 OS=Bos taurus OX=9913 GN=CNTN1 PE=2 SV=1 MKMWLLFSLLVIISFKTCLSEFTWHRRYGHGVSEEDKGFGPIFEEQPINTIYPEESPEGK VSLNCRARASPFPVYKWRMNNGDIDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNY GMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVF ITMDKRRFVSQTNGNLYIANVEASDKGN*208YSCFVSSPSITKSVFSKFIPLIPLPERTTKPY PADIVVQFKDVYALMGQN*258VTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNI QLEDEGIYECEAENNRGKDKHQARIYVQAFPEWVEHIN*338DTEVDIGSDLYWPCVATGKPIP TIRWLKNGYSYHRGELRLYDVTFENAGMYQCIAENTHGAIYANAELKILALAPTFEMNPM KKKILAAKGGRVIIECKPKAAPKPTFLWSKGTERLVN*457SSRILIWEDGSLEINN*473ITRSDGG VYTCFVENNKGKAN*494STGTLVITDPTRIILAPINADITVGEN*521ATMQCAASFDPALDLTFVW SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDN*591SSASADLVV RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE GNMEAARAVDLIPWMEYEFRVVATNTLGIGEPSIPSNKIKTDGAAPNVAPSDVGGGGGSN RELTITWAPLSREYHYFNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMRPSTAF QVKVKAFNNKGDGPYSLTAVIHSAQDAPSEAPTAVGVKVLSSSEISVHWEHVVEKIVESY QIRYWASHDKEAAAHRVQVASQEYSARLENLLPDTQYFVEVRACNSAGCGPPSDMTETFT KKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKH SIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGASILSPCLLGFLLPALGILVYLEF
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (994-1016)
Significance of PTMs glycosylation has a role in cell adhesion.
Bibliography 1.Zhang, Q., Ma, C., Chin, L. S., & Li, L. (2020). Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer's disease. Science advances, 6(40), eabc5802. https://doi.org/10.1126/sciadv.abc5802 2.Watanabe, K., Shimazaki, K., Hosoya, H., Fukamauchi, F., & Takenawa, T. (1995). Cloning of the cDNA encoding neural adhesion molecule F3 from bovine brain. Gene, 160(2), 245–248. https://doi.org/10.1016/0378-1119(95)00062-b