Primary Information
BoMiProt ID	Bomi4810
Protein Name	Collagen alpha-1(X) chain
Organism	Bos taurus
Uniprot ID	P23206
Milk Fraction	Whey
Ref Sequence ID	NP_777059.1
Aminoacid Length	674
Molecular Weight	65546
FASTA Sequence	Download
Gene Name	COL10A1
Gene ID	282416
Protein Existence Status	reviewed
Secondary Information
Protein Function	Synthesis of Collagen X is related to differnetiation matiration and proliferation of chondrocytes( Chondrocyte hypertrophy).An increase in the number of matrix vesicles,an increase in alkaline phosphatase activity and the generation of a calcified matrix, which is subsequently replaced by bone.
Biochemical Properties	A homotrimer condensed structure. short triple helical collagen domain flanked by the N-terminal NC2 and the C-terminal NC1 domains. The C-terminal NC1 domain has complement C1q-like structure.Collagen X forms hexamer complexes through the association of NC1 regions.The overlapping cDNA clones encode 3144 bp with a 5'-terminal untranslated region of 148 bp, a 2025 bp reading frame and a 3'-terminal untranslated region of 971 bp.The interchain disulphide-bonding observed previously within the triple helix of bovine type X collagen is explained by the presence of two cysteine residues within an imperfection of the triple-helical domain encoded by -Gly-Xaa-Cys-Xaa-Yaa-Cys-Xaa-Yaa-Gly-.
PTMs	Hydroxylation on Pro-460 and Pro0463
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	na
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
Bibliography	Thomas JT, Kwan AP, Grant ME, Boot-Handford RP. Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes. Biochem J. 1991 Jan 1;273(Pt 1)(Pt 1):141-8. doi: 10.1042/bj2730141. PMID: 1703407; PMCID: PMC1149890.