Primary Information |
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BoMiProt ID | Bomi4810 |
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Protein Name | Collagen alpha-1(X) chain |
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Organism | Bos taurus |
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Uniprot ID | P23206 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_777059.1 |
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Aminoacid Length | 674 |
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Molecular Weight | 65546 |
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FASTA Sequence |
Download |
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Gene Name | COL10A1 |
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Gene ID | 282416 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | Synthesis of Collagen X is related to differnetiation matiration and proliferation of chondrocytes( Chondrocyte hypertrophy).An increase in the
number of matrix vesicles,an increase in alkaline phosphatase activity and the generation of a calcified matrix, which is subsequently replaced by bone. |
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Biochemical Properties | A homotrimer condensed structure. short triple helical collagen domain flanked by the N-terminal NC2 and the C-terminal NC1 domains. The C-terminal NC1 domain has complement C1q-like structure.Collagen X forms hexamer complexes through the association of NC1 regions.The overlapping cDNA clones encode 3144 bp with a 5'-terminal untranslated region of 148 bp, a 2025 bp reading frame and a 3'-terminal untranslated region of 971 bp.The interchain disulphide-bonding observed previously within the triple helix of bovine type X collagen is explained by the presence of two cysteine residues within an imperfection of the triple-helical domain encoded by -Gly-Xaa-Cys-Xaa-Yaa-Cys-Xaa-Yaa-Gly-. |
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PTMs | Hydroxylation on Pro-460 and Pro0463 |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. |
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Bibliography | Thomas JT, Kwan AP, Grant ME, Boot-Handford RP. Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes. Biochem J. 1991 Jan 1;273(Pt 1)(Pt 1):141-8. doi: 10.1042/bj2730141. PMID: 1703407; PMCID: PMC1149890. |