Search by BoMiProt ID - Bomi4749


Primary Information

BoMiProt ID Bomi4749
Protein Name Coagulation factor X/Stuart factor
Organism Bos taurus
Uniprot IDP00743
Milk FractionWhey
Aminoacid Length 492
Molecular Weight 54510
FASTA Sequence Download
Gene Name F10
Gene ID 280787
Protein Existence Status reviewed

Secondary Information

Protein Function Human coagulation factor X has a central role within the blood coagulation system making it an attractive target for the development of alternative treatment strategies for patients with hemophilia. 
Biochemical Properties FXa promotes immune evasion by signaling through protease-activated receptor 2 and that rivaroxaban specifically targets this cell-autonomous signaling pathway to reprogram tumor-associated macrophages.
PTMs  Disulfide bond formation, Glycosylation, Hydroxylation, Sulfation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P00743|FA10_BOVIN Coagulation factor X OS=Bos taurus OX=9913 GN=F10 PE=1 SV=1 MAGLLHLVLLSTALGGLLRPAGSVFLPRDQAHRVLQRARRANSFLEEVKQGNLERECLEE ACSLEEAREVFEDAEQTDEFWSKYKDGDQCEGHPCLNQGHCKDGIGDYTCTCAEGFEGKN CEFSTREICSLDNGGCDQFCREERSEVRCSCAHGYVLGDDSKSCVSTERFPCGKFTQGRS RRWAIHTSEDALDASELEHYDPADLSPT*208ESSLDLLGLN*218RTEPSAGEDGSQVVRIVGGRDC AEGECPWQALLVNEENEGFCGGTILNEFYVLTAAHCLHQAKRFTVRVGDRNTEQEEGNEM AHEVEMTVKHSRFVKETYDFDIAVLRLKTPIRFRRNVAPACLPEKDWAEATLMTQKTGIV SGFGRTHEKGRLSSTLKMLEVPYVDRSTCKLSSSFTITPNMFCAGYDTQPEDACQGDSGG PHVTRFKDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIDKIMKARAGAAGSRGHSEA PATWT*485VPPPLPL
SCOP Class : Small proteins
Fold : GLA-domain
Superfamily : GLA-domain
Family : GLA-domain
Domain Name : 1IOD G:401-444

Class : Small proteins
Fold : Knottins (small inhibitors, toxins, lectins)
Superfamily : EGF/Laminin-like
Family : EGF-type module
Domain Name : 1KIG L:389-439

Class : All beta proteins
Fold : Trypsin-type beta(6)-barrel
Superfamily : Trypsin-like serine proteases
Family : Eukaryotic proteases
Domain Name : 1KIG H:16-251

CATH Matched CATH superfamily
4.10.740.10
2.10.25.10
2.40.10.10
Predicted Disorder Regions 471-491
DisProt Annotation
TM Helix Prediction No TM helices
PDB ID 1APO,1CCF,1IOD,1KIG,1WHE,1WHF,
Additional Comments FX interaction with macrophages through its N-glycans protects it from a rapid clearance explaining its relatively long circulatory half-life.
Bibliography 1.Ebert M, Raquet E, Schweisgut S, Schmidt PM, Weimer T. Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent. Blood Cells Mol Dis. 2021 Jul;89:102570. doi: 10.1016/j.bcmd.2021.102570. Epub 2021 Apr 23. PMID: 33962291. 2.Graf C, Wilgenbus P, Pagel S, Pott J, Marini F, Reyda S, Kitano M, Macher-Göppinger S, Weiler H, Ruf W. Myeloid cell-synthesized coagulation factor X dampens antitumor immunity. Sci Immunol. 2019 Sep 20;4(39):eaaw8405. doi: 10.1126/sciimmunol.aaw8405. PMID: 31541031; PMCID: PMC6830514. 3.Kurdi M, Cherel G, Lenting PJ, Denis CV, Christophe OD. Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance. PLoS One. 2012;7(9):e45111. doi: 10.1371/journal.pone.0045111. Epub 2012 Sep 25. PMID: 23049768; PMCID: PMC3458019.