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Primary Information | |
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| BoMiProt ID | Bomi4749 |
| Protein Name | Coagulation factor X/Stuart factor |
| Organism | Bos taurus |
| Uniprot ID | P00743 |
| Milk Fraction | Whey |
| Aminoacid Length | 492 |
| Molecular Weight | 54510 |
| FASTA Sequence | Download |
| Gene Name | F10 |
| Gene ID | 280787 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | Human coagulation factor X has a central role within the blood coagulation system making it an attractive target for the development of alternative treatment strategies for patients with hemophilia. |
| Biochemical Properties | FXa promotes immune evasion by signaling through protease-activated receptor 2 and that rivaroxaban specifically targets this cell-autonomous signaling pathway to reprogram tumor-associated macrophages. |
| PTMs | Disulfide bond formation, Glycosylation, Hydroxylation, Sulfation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P00743|FA10_BOVIN Coagulation factor X OS=Bos taurus OX=9913 GN=F10 PE=1 SV=1 MAGLLHLVLLSTALGGLLRPAGSVFLPRDQAHRVLQRARRANSFLEEVKQGNLERECLEE ACSLEEAREVFEDAEQTDEFWSKYKDGDQCEGHPCLNQGHCKDGIGDYTCTCAEGFEGKN CEFSTREICSLDNGGCDQFCREERSEVRCSCAHGYVLGDDSKSCVSTERFPCGKFTQGRS RRWAIHTSEDALDASELEHYDPADLSPT*208ESSLDLLGLN*218RTEPSAGEDGSQVVRIVGGRDC AEGECPWQALLVNEENEGFCGGTILNEFYVLTAAHCLHQAKRFTVRVGDRNTEQEEGNEM AHEVEMTVKHSRFVKETYDFDIAVLRLKTPIRFRRNVAPACLPEKDWAEATLMTQKTGIV SGFGRTHEKGRLSSTLKMLEVPYVDRSTCKLSSSFTITPNMFCAGYDTQPEDACQGDSGG PHVTRFKDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIDKIMKARAGAAGSRGHSEA PATWT*485VPPPLPL |
| SCOP | Class : Small proteins Fold : GLA-domain Superfamily : GLA-domain Family : GLA-domain Domain Name : 1IOD G:401-444 Class : Small proteins Fold : Knottins (small inhibitors, toxins, lectins) Superfamily : EGF/Laminin-like Family : EGF-type module Domain Name : 1KIG L:389-439 Class : All beta proteins Fold : Trypsin-type beta(6)-barrel Superfamily : Trypsin-like serine proteases Family : Eukaryotic proteases Domain Name : 1KIG H:16-251 |
| CATH | Matched CATH superfamily 4.10.740.10 2.10.25.10 2.40.10.10 |
| Predicted Disorder Regions | 471-491 |
| DisProt Annotation | |
| TM Helix Prediction | No TM helices |
| PDB ID | 1APO,1CCF,1IOD,1KIG,1WHE,1WHF, |
| Additional Comments | FX interaction with macrophages through its N-glycans protects it from a rapid clearance explaining its relatively long circulatory half-life. |
| Bibliography | 1.Ebert M, Raquet E, Schweisgut S, Schmidt PM, Weimer T. Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent. Blood Cells Mol Dis. 2021 Jul;89:102570. doi: 10.1016/j.bcmd.2021.102570. Epub 2021 Apr 23. PMID: 33962291. 2.Graf C, Wilgenbus P, Pagel S, Pott J, Marini F, Reyda S, Kitano M, Macher-Göppinger S, Weiler H, Ruf W. Myeloid cell-synthesized coagulation factor X dampens antitumor immunity. Sci Immunol. 2019 Sep 20;4(39):eaaw8405. doi: 10.1126/sciimmunol.aaw8405. PMID: 31541031; PMCID: PMC6830514. 3.Kurdi M, Cherel G, Lenting PJ, Denis CV, Christophe OD. Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance. PLoS One. 2012;7(9):e45111. doi: 10.1371/journal.pone.0045111. Epub 2012 Sep 25. PMID: 23049768; PMCID: PMC3458019. |