Primary Information |
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| BoMiProt ID | Bomi4708 |
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| Protein Name | Chymotrypsin-like elastase family member 2A/Elastase II/Elastase-2/Elastase-2A |
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| Organism | Bos taurus |
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| Uniprot ID | Q29461 |
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| Milk Fraction | Whey,Casein |
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| Ref Sequence ID | NP_777139.1 |
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| Aminoacid Length | 269 |
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| Molecular Weight | 28857 |
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| FASTA Sequence |
Download |
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| Gene Name | CELA2A/ELA2/ ELA2A |
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| Gene ID | 282687 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | circulating enzyme that reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. |
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| Biochemical Properties | exocrine pancreatic elastase that preferentially cleaves A-acetyl-L-alanyl-L-alanyl-L-alanine/proline methyl-ester.There is a C-to-A transversion (chr1.15,789,253C-A, GRCh37) in the CELA2A gene, resulting in a leu85-to-met (L85M) substitution at a highly conserved residue within the catalytic domain which is the cause of ABDOMINAL OBESITY-METABOLIC SYNDROME 4.The catalytic triad is made up of his45, asp93, and ser188. |
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| PTMs | Disulfide bond, proteolytic digestion |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Esteghamat, F., Broughton, J.S., Smith, E. et al. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nat Genet 51, 1233–1243 (2019). https://doi.org/10.1038/s41588-019-0470-32.Szepessy E, Sahin-Tóth M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. Pancreatology. 2006;6(1-2):117-22. doi: 10.1159/000090031. Epub 2005 Dec 1. PMID: 16327289; PMCID: PMC1447606. |
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