Primary Information |
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| BoMiProt ID | Bomi4670 |
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| Protein Name | Choline transporter-like protein 4/Solute carrier family 44 member 4/Thiamine pyrophosphate transporter 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A3KMY4 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001076911.1 |
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| Aminoacid Length | 707 |
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| Molecular Weight | 78938 |
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| FASTA Sequence |
Download |
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| Gene Name | SLC44A4/CTL4/TPPT1 |
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| Gene ID | 520625 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | Intestine, kidney, stomach |
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| Protein Function | Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury.Also act as thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis. |
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| PTMs | N-glycosylated |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A3KMY4|CTL4_BOVIN Choline transporter-like protein 4 OS=Bos taurus OX=9913 GN=SLC44A4 PE=2 SV=1
MGGKQDQDKEAYGKPAKYDPSFRGPIRNRSCTDIICCVLFFLFILGYIAVGILAWVYGDP
KQVLYPRN*68STGAYCGIGENKEKPYLLYFNIFSCVLNTNIIAIAQNGLKCPTPQVCVSSCP
EASWTVEPRQFSQTVEQVFYAANRNFCLPGVPGNMQVLQSLQQELCPSFLLPSTPALGRC
FPWTN*185STVPELPGISN*196TSISQSISGLLDSLNARDISVKIFEDFAQSWYWILIALGLALVL
SLLFILLLRLVAGPLVFVLIIGVLGVLAYGIYHCWEEYRVLRDKGASISQLGFTTN*296LSAY
RNVQETWLAALIILAVLEGVLLLMLIFLRQRICIAIALLKEASRAVGYIMSTMFYPLVTF
ALLLVCIAYWAIIALFLATSGQPQYVFWAPN*391SSLPGCEKVPMN*403TSCDPMEQVN*413SSCPGLM
CVFQGYQSTGLAQRSLFNLQIYAVLGLFWTINWVLALGQCVLAGAFASFYWAFHKPRDIP
TFPLGSAFLRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGAQNPLTRCILCCFKC
CLWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVRVVVLDKVTDLLLFFGK
LLVVGGVGVLSFFFFTGRIPSLGKTFENPQLNYYWLPIMVSILGAYLIASGFFSVFGMCV
DTLFLCFLEDLERNDGSADRPYYMSKSLLKILGKKNKGTPGDKKRKK
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| Predicted Disorder Regions | 1-15, 694-707 |
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| DisProt Annotation | |
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| TM Helix Prediction | 10TMHs; (35-57),(226-248),(255-273),(306-328),(354-376),(451-473),(494-516),(556-574),(594-616),(635-657) |
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| Significance of PTMs | N-glycosylation of Asn-68 and Asn-391 is required for a proper thiamine pyrophosphate uptake. |
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| Additional Comments | knockdown of CTL4 significantly decreased ACh secretion. Conversely, an increase in the expression of CTL4 increased ACh secretion. |
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| Bibliography | Inazu M. Choline transporter-like proteins CTLs/SLC44 family as a novel molecular target for cancer therapy. Biopharm Drug Dispos. 2014 Nov;35(8):431-49. doi: 10.1002/bdd.1892. Epub 2014 Feb 27. PMID: 24532461. |
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